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NONACTIN

Product Name
NONACTIN
CAS No.
6833-84-7
Chemical Name
NONACTIN
Synonyms
3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
CBNumber
CB2424675
Molecular Formula
C40H64O12
Formula Weight
736.93
MOL File
6833-84-7.mol
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NONACTIN Property

Melting point:
147-148°
Boiling point:
890.6±65.0 °C(Predicted)
Density 
1.11-1.15 g/cm3
storage temp. 
2-8°C
solubility 
chloroform: soluble10mg/mL
form 
White to off-white crystalline solid.
color 
white to faint yellow
Sensitive 
Moisture Sensitive
Merck 
13,6709
BRN 
76434
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
RH1685000
10-21
HS Code 
29321900
Toxicity
LD50 intravenous in mouse: 246mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
09877
Product name
Ammonium ionophore I
Purity
Selectophore
Packaging
50mg
Price
$389
Updated
2024/03/01
Sigma-Aldrich
Product number
09877
Product name
Ammonium ionophore I
Purity
Selectophore
Packaging
250mg
Price
$1780
Updated
2024/03/01
Cayman Chemical
Product number
19468
Product name
Nonactin
Purity
≥95%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
19468
Product name
Nonactin
Purity
≥95%
Packaging
10mg
Price
$87
Updated
2024/03/01
Sigma-Aldrich
Product number
N2286
Product name
Nonactin
Purity
≥98% (function tested, HPLC)
Packaging
10mg
Price
$188
Updated
2024/03/01
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NONACTIN Chemical Properties,Usage,Production

Description

Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3

Chemical Properties

Light yellow powder

Uses

Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.

Uses

Nonactin is an ionophore antiobiotic that selectively binds K+?and NH4+.

Definition

ChEBI: Nonactin is a macrotetrolide.

Biological Activity

Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.

Purification Methods

This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]

References

1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11 2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664 3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95

NONACTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NONACTIN Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2997
Advantage
55
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View Lastest Price from NONACTIN manufacturers

Career Henan Chemical Co
Product
NONACTIN 6833-84-7
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

6833-84-7, NONACTINRelated Search:


  • ta-25-m-i
  • NONACTIN
  • NONACTIN, STREPTOMYCES GRISEUS
  • POLYNACTIN
  • NONACTIN FROM STREPTOMYCES GRISEUS
  • NONACTINE, FROM STREPTOMYCES SP.
  • NONACTIN FROM STREPTOMYCES TSUSIMAENSIS
  • nonactinfromstreptomycessp.
  • NONACTINE, STREPTOMYCES GRISEUS
  • Nonactin, Amonium Ionophore, Werramycin A, Polynactin
  • Ammonium ionophore, Nonactin
  • (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
  • WerraMycin, FH 3582A, NSC 52141, AKD 1A, KD 1A
  • Nonactin / 5342 Pfw 19 / A 4426 / Ammonium ionophore I
  • Nonactin from Streptomyces griseus var griseus
  • AMMONIUM IONOPHORE
  • AMMONIUM IONOPHORE I
  • WERRAMYCIN A
  • -(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*)
  • 28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r
  • 3584-a
  • 4,13,22,31,37,38,39,40-octaoxapentacyclo(32.2.1.1(sup7,10).1(sup16,19).1(sup
  • a-5584
  • e-79-c
  • fh-3582-a
  • n-329-a
  • 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
  • NONACTIN USP/EP/BP
  • Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade)
  • Nonactin, Monactin, and Dinactin Mixture
  • 6833-84-7
  • C40H64O12
  • Antibiotics A to Z
  • Antibiotics N-S
  • Antibiotics
  • Ionophores Potentiometric for ISE
  • Ion Sensor Materials
  • BioChemical
  • Analytical Chromatography Product Catalog
  • inhibitor