Methyl (R)-(-)-3-hydroxybutyrate

Product Name: Methyl (R)-(-)-3-hydroxybutyrate
CAS No.: 3976-69-0
Chemical Name: Methyl (R)-(-)-3-hydroxybutyrate
Synonyms: METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;Methyl (R)-(-)-3-hyd;R-hydroxy butyl etherate;methyl R-3-hydroxybutanoate;METHYL (R)-3-HYDROXYBUTYRATE;METHYL 3-(R)-HYDROXYBUTYRATE;Methyl (3R)-hydroxybutanoate;METHYL D-(R)-3-HYDROXYBUTYRATE;Methyl (R)-(-)-3-hydroxybutyra
CBNumber: CB9682595
Molecular Formula: C5H10O3
Formula Weight: 118.13
MOL File: 3976-69-0.mol

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Methyl (R)-(-)-3-hydroxybutyrate Property

alpha: -21.5 º (neat)
Boiling point:: 56-58 °C/11 mmHg (lit.)
Density: 1.055 g/mL at 20 °C (lit.)
refractive index: n20/D 1.421(lit.)
Flash point:: 161 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
pka: 13.95±0.20(Predicted)
color: Colourless
optical activity: [α]20/D 19.5°, neat
Water Solubility: Slightly soluble in water.
BRN: 3648161
InChI: InChI=1S/C5H10O3/c1-4(6)3-5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
InChIKey: LDLDJEAVRNAEBW-SCSAIBSYSA-N
SMILES: C(OC)(=O)C[C@H](O)C
LogP: -0.412 (est)
CAS DataBase Reference: 3976-69-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37-24/25-23
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 243159
Product name: Methyl (R)-3-hydroxybutyrate
Purity: 99%
Packaging: 1g
Price: $101
Updated: 2024/03/01

TCI Chemical

Product number: H0705
Product name: Methyl (R)-(-)-3-Hydroxybutyrate
Purity: >98.0%(GC)
Packaging: 10mL
Price: $31
Updated: 2023/06/20

TCI Chemical

Product number: H0705
Product name: Methyl (R)-(-)-3-Hydroxybutyrate
Purity: >98.0%(GC)
Packaging: 25mL
Price: $60
Updated: 2023/06/20

Alfa Aesar

Product number: L14151
Product name: Methyl (R)-(-)-3-hydroxybutyrate, 98%
Packaging: 1g
Price: $34.65
Updated: 2024/03/01

Alfa Aesar

Product number: L14151
Product name: Methyl (R)-(-)-3-hydroxybutyrate, 98%
Packaging: 5g
Price: $95.65
Updated: 2024/03/01

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Methyl (R)-(-)-3-hydroxybutyrate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Methyl (R)-3-hydroxybutyrate may be used in the preparation of (R)-(-)-3-hydroxybutanoic acid and poly-(R)-(-)-3-hydroxybutyrate.

General Description

Methyl (R)-(-)-3-hydroxybutyrate is a monocarboxylic acid that is metabolized by phosphofructokinase and other enzymes to produce the corresponding 3-hydroxybutyrate. This compound is synthesized from tiglic acid, which can be obtained from corynebacterium. The production of it can be optimized by using a biotransformation process.

Synthesis

In the glove box, put RuCl3 (0.69mg, 0.0033mmol), (R)-BINAP (2.3mg, 0.0036mmol), (1R,2R)-1,2-diphenyl-1,2-ethylenediamine (0.78 mg, 0.0036mmol) and isopropanol (150g) were added to a single-necked flask equipped with a magnetic stirrer, the stirring was turned on, the metal precursor and the ligand were dissolved and coordinated for 30 minutes,Obtain the catalyst solution, seal the single-neck bottle, take it out of the glove box, and pump it into a 0.5L reactor with a flat flow pump under the protection of nitrogen. The reactor has been replaced with nitrogen in advance, and the substrate methyl acetoacetate (116g, 1mol) and Potassium tert-butoxide (0.12g).After the catalyst solution was added, the reactor was replaced with hydrogen for three times, 8MPa hydrogen was charged, and the reactor was turned on for stirring and heating.When the internal temperature of the reactor reaches 100°C, open the hydrogen gas inlet valve, keep the internal pressure of the reactor at 10MPa, start timing, keep the reaction for 5 hours, the flowmeter shows that the hydrogen absorption rate is less than 0.1mL/min, terminate the reaction, and cool the reactor To room temperature, sampling and GC analysis showed that the conversion rate of raw material methyl acetoacetate was 99.9%, and the selectivity of (R)-1,3-butanediol was 8.8%.The ee value is 99.2%, and the selectivity of Methyl (R)-(-)-3-hydroxybutyrate is 90.9%.

Methyl (R)-(-)-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl (R)-(-)-3-hydroxybutyrate Suppliers

Americas 1 Belgium 2 Canada 1 China 255 Europe 1 France 2 Germany 10 India 15 Japan 6 Slovakia 1 Switzerland 6 United Kingdom 13 United States 36 Global 349

Ningbo biermann pharmaceutical technology co., LTD

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View Lastest Price from Methyl (R)-(-)-3-hydroxybutyrate manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-27

Hebei Guanlang Biotechnology Co,.LTD

Product: Methyl (R)-(-)-3-Hydroxybutyrate 3976-69-0
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2023-05-24

ChiRial Biomaterial Co Ltd

Product: Methyl (R)-(-)-3-Hydroxybutyrate 3976-69-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 10 tons
Release date: 2023-03-23

3976-69-0, Methyl (R)-(-)-3-hydroxybutyrateRelated Search:

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Methyl (R)-(-)-3-Hydroxybutyrate(3976-69-0)

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3976-69-0

Asymmetric Synthesis

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