(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE

Product Name: (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE
CAS No.: 185517-74-2
Chemical Name: (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE
Synonyms: S-PAI;TV 1022;TVP 1022;(S)-Rasagiline;(S)- Resagiline;Rasagiline S-Isomer;(S)-RASAGILINE;S-PAI;TVP1022 >=98% (HPLC);(S) Rasagiline,(S)Rasagiline;S-(-)-N-Propargyl-1-aminoindan
CBNumber: CB2429463
Molecular Formula: C12H13N
Formula Weight: 171.24
MOL File: 185517-74-2.mol

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(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE Property

Boiling point:: 305.5±30.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥15mg/mL
form: powder
pka: 6.95±0.20(Predicted)
color: Light yellow to yellow

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: NK8216500
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0222
Product name: TVP1022
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $97.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0222
Product name: TVP1022
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $374
Updated: 2025/07/31

Apolloscientific

Product number: OR953162
Product name: (S)-N-(2-Propynyl)-2,3-dihydroinden-1-amine
Purity: 95%
Packaging: 1g
Price: $435
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0166294
Product name: (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE
Purity: 98.00%
Packaging: 5MG
Price: $504.17
Updated: 2021/12/16

Activate Scientific

Product number: AS23704
Product name: (S)-N-(2-Propynyl)-2,3-dihydroinden-1-amine
Purity: 97+% ee
Packaging: 1g
Price: $575
Updated: 2021/12/16

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(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE Chemical Properties,Usage,Production

Uses

(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in r at models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

References

[1] M B Youdim, et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132(2):500-6. DOI:10.1038/sj.bjp.0703826

(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE Suppliers

China 66 India 4 United States 12 Global 82

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185517-74-2, (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINERelated Search:

5-DIMETHYLAMINO-1-NAPHTHALENESULFONIC ACID HYDRATE Pargyline (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE

(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE

(S)-N-(2-Propynyl)-2,3-dihydroinden-1-aMine

S-(-)-N-Propargyl-1-aminoindan

S-PAI

(S)-Rasagiline

TV 1022

TVP 1022

(S)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine

(1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine

(1S)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine

(S)-RASAGILINE;S-PAI

1H-Inden-1-amine, 2,3-dihydro-N-2-propyn-1-yl-, (1S)-

TVP1022 >=98% (HPLC)

(1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine

Rasagiline S-Isomer

(S)-RasagilineQ: What is (S)-Rasagiline Q: What is the CAS Number of (S)-Rasagiline Q: What is the storage condition of (S)-Rasagiline Q: What are the applications of (S)-Rasagiline

(S) Rasagiline,(S)Rasagiline

(S)- Resagiline

185517-74-2