Pargyline
- Product Name
- Pargyline
- CAS No.
- 555-57-7
- Chemical Name
- Pargyline
- Synonyms
- MO 911;A 19120;Eudatin;Eutonyl;Supirdyl;Pargylin;PARGYLINE;Paragyline;Pargylamine;AURORA KA-7798
- CBNumber
- CB8698159
- Molecular Formula
- C11H13N
- Formula Weight
- 159.23
- MOL File
- 555-57-7.mol
Pargyline Property
- Melting point:
- 15-20 °C
- Boiling point:
- 86-88 °C4 mm Hg(lit.)
- Density
- 0.944 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.522(lit.)
- Flash point:
- 183 °F
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Liquid
- pka
- pKa 6.9 (Uncertain)
- color
- Clear yellow
- Merck
- 14,7038
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25-36/37/38-22
- Safety Statements
- 26-36/37/39-45-23
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DP6475000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29214900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M74253
- Product name
- N-Methyl-N-propargylbenzylamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $145
- Updated
- 2024/03/01
- Product number
- M74253
- Product name
- N-Methyl-N-propargylbenzylamine
- Purity
- 97%
- Packaging
- 25g
- Price
- $570
- Updated
- 2024/03/01
- Product number
- M2618
- Product name
- N-Methyl-N-propargylbenzylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $154
- Updated
- 2024/03/01
- Product number
- M2618
- Product name
- N-Methyl-N-propargylbenzylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $629
- Updated
- 2021/12/16
- Product number
- 38066
- Product name
- Pargyline,≥98%(Assaybytitration,GC)Hazmat
- Purity
- ≥98%(Assaybytitration,GC)
- Packaging
- 5G
- Price
- $686.07
- Updated
- 2021/12/16
Pargyline Chemical Properties,Usage,Production
Chemical Properties
CLEAR YELLOW LIQUID
Originator
Eutonyl, Abbott , US ,1963
Uses
analgesic
Definition
ChEBI: Pargyline is an aromatic amine.
Manufacturing Process
A mixture of 23.8 grams (0.2 mol) of propargyl bromide, 24.2 grams (0.2 mol) of N-methylbenzylamine and 400 ml of anhydrous ethanol in the presence of 42.4 grams (0.4 mol) of anhydrous sodium carbonate was heated at the boiling temperature and under reflux for a period of 17 hours.
The sodium carbonate was then removed by filtration and the alcohol was removed by distillation under reduced pressure. The residue was treated with 300 ml of dry ether and the resulting solution was filtered to remove sodium bromide.
The filtrate was dried and fractionally distilled under reduced pressure to obtain the desired N-methyl-N-propargylbenzylamine which boiled at 96°97°C at 11 mm pressure.
Analysis calculated for C11H13N: C = 82.97%; H = 8.23%; N = 8.80%. Found: C = 82.71%; H = 8.51%; N = 8.93%.
The hydrochloride salt of this amine was prepared by dissolving the amine in ether and adding ethereal hydrogen chloride to the ether solution. The solid hydrochloride salt which precipitated was recrystallized from an ethanol-ether mixture and was found to melt at 154° - 155°C.
brand name
Eutonyl (Abbott).
Therapeutic Function
Antihypertensive
Enzyme inhibitor
This antihypertensive agent (FWfree-base = 159.23 g/mol; CAS 555-57-7), also known as Eutonyl, N-benzyl-N-methyl-2-propynylamine, is amechanism-based inhibitor that targets monoamine oxidase, beginning with an initial reversible interaction (Ki = 4-5 μM) and proceeding to irreversible loss of enzyme activity. Target(s): aldehyde dehydrogenase, pargyline is the precursor of the actual inhibitor; bacterial bioluminescence; and monoamine oxidase.
Pargyline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pargyline manufacturers
- Product
- Pargyline 555-57-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Pargyline 555-57-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09