ChemicalBook > CAS DataBase List > Pargyline

Pargyline

Product Name
Pargyline
CAS No.
555-57-7
Chemical Name
Pargyline
Synonyms
MO 911;A 19120;Eudatin;Eutonyl;Supirdyl;Pargylin;PARGYLINE;Paragyline;Pargylamine;AURORA KA-7798
CBNumber
CB8698159
Molecular Formula
C11H13N
Formula Weight
159.23
MOL File
555-57-7.mol
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Pargyline Property

Melting point:
15-20 °C
Boiling point:
86-88 °C4 mm Hg(lit.)
Density 
0.944 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.522(lit.)
Flash point:
183 °F
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Liquid
pka
pKa 6.9 (Uncertain)
color 
Clear yellow
Merck 
14,7038
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-36/37/38-22
Safety Statements 
26-36/37/39-45-23
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
DP6475000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29214900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M74253
Product name
N-Methyl-N-propargylbenzylamine
Purity
97%
Packaging
5g
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
M74253
Product name
N-Methyl-N-propargylbenzylamine
Purity
97%
Packaging
25g
Price
$570
Updated
2024/03/01
TCI Chemical
Product number
M2618
Product name
N-Methyl-N-propargylbenzylamine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$154
Updated
2024/03/01
TCI Chemical
Product number
M2618
Product name
N-Methyl-N-propargylbenzylamine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$629
Updated
2021/12/16
Chem-Impex
Product number
38066
Product name
Pargyline,≥98%(Assaybytitration,GC)Hazmat
Purity
≥98%(Assaybytitration,GC)
Packaging
5G
Price
$686.07
Updated
2021/12/16
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Pargyline Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Originator

Eutonyl, Abbott , US ,1963

Uses

analgesic

Definition

ChEBI: Pargyline is an aromatic amine.

Manufacturing Process

A mixture of 23.8 grams (0.2 mol) of propargyl bromide, 24.2 grams (0.2 mol) of N-methylbenzylamine and 400 ml of anhydrous ethanol in the presence of 42.4 grams (0.4 mol) of anhydrous sodium carbonate was heated at the boiling temperature and under reflux for a period of 17 hours.
The sodium carbonate was then removed by filtration and the alcohol was removed by distillation under reduced pressure. The residue was treated with 300 ml of dry ether and the resulting solution was filtered to remove sodium bromide.
The filtrate was dried and fractionally distilled under reduced pressure to obtain the desired N-methyl-N-propargylbenzylamine which boiled at 96°97°C at 11 mm pressure.
Analysis calculated for C11H13N: C = 82.97%; H = 8.23%; N = 8.80%. Found: C = 82.71%; H = 8.51%; N = 8.93%.
The hydrochloride salt of this amine was prepared by dissolving the amine in ether and adding ethereal hydrogen chloride to the ether solution. The solid hydrochloride salt which precipitated was recrystallized from an ethanol-ether mixture and was found to melt at 154° - 155°C.

brand name

Eutonyl (Abbott).

Therapeutic Function

Antihypertensive

Enzyme inhibitor

This antihypertensive agent (FWfree-base = 159.23 g/mol; CAS 555-57-7), also known as Eutonyl, N-benzyl-N-methyl-2-propynylamine, is amechanism-based inhibitor that targets monoamine oxidase, beginning with an initial reversible interaction (Ki = 4-5 μM) and proceeding to irreversible loss of enzyme activity. Target(s): aldehyde dehydrogenase, pargyline is the precursor of the actual inhibitor; bacterial bioluminescence; and monoamine oxidase.

Pargyline Preparation Products And Raw materials

Raw materials

3-Chloropropyne N-Methylbenzylamine

Preparation Products

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View Lastest Price from Pargyline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pargyline 555-57-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

555-57-7, PargylineRelated Search:

N-(4-CHLORO-2-BUTYNYL)PHTHALIMIDE N-METHYL-N-PROPARGYLBENZYLAMINE HYDROCHLORIDE,N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride N-PROPARGYLPHTHALIMIDE Pargyline PROPARGYLAMINE 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE 4-[N-ETHYL-(4-METHOXYPHENYL)METHYLAMINO]-2-BUTYNYL-2-CYCLOHEXYL-2-HYDROXYBENZENE ACETATE 5-PHTHALIMIDO-3-PENTYNE (R)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE 4-[N-ETHYL-(4-METHOXYPHENYL)METHYLAMINO]-2-BUTYNYL-1-OL 1-PHTHALIMIDO-2-BUTYNE (S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE N-METHYL-N-PROPARGYL-4-(CYCLOHEPTYLCARBONYLAMINO)-2-CHLOROBENZAMIDE 4-METHYL-6-PHENYL-3-(PHENYLSULFONYL)-1-(2-PROPYNYL)-2(1H)-PYRIDINONE AURORA KA-7621 N-METHYL-N-PROPARGYL-4-(TETRAHYDROFURAN-2-YLCARBONYLAMINO)-2-CHLOROBENZAMIDE N-METHYL-N-PROPARGYL-4-AMINO-2-CHLOROBENZAMIDE cis-N-(4-(2,6-Dimethylpiperidino)but-2-ynyl)phthalimide

  • AURORA KA-7798
  • PARGYLINE
  • N-METHYL-N-PROPARGYLBENZYLAMINE
  • benzyl(methyl)prop-2-ynylamine
  • N-Methyl-N-propargylbenzylamine,97%
  • N-Methyl-N-propargylbenzylaminePargyline
  • Pargylamine
  • Pargylin
  • Supirdyl
  • BenzeneMethanaMine, N-Methyl-N-2-propynyl-
  • A 19120
  • Benzylamine, N-methyl-N-2-propynyl-
  • Benzyl-methyl-2-propinylamin
  • Eudatin
  • Eutonyl
  • MO 911
  • N-Benzyl-N-methyl-2-propyn-1-amine
  • N-Benzyl-N-methyl-2-propynylamine
  • n-methyl-n-2-propynyl-benzylamin
  • N-Methyl-N-2-propynylbenzylamine
  • N-Methyl-N-Benzylpropynylamine
  • Paragyline
  • N-Benzyl-N-methylpropargylamine
  • N-Methyl-N-2-propynylbenzenemethanamine
  • N-benzyl-N-Methylprop-2-yn-1-aMine
  • N-Methyl-N-propargylbenzylaMine 97%
  • N-methyl-N-2-propyn-1-yl-Benzenemethanamine
  • <i>N</i>-Methyl-<i>N</i>-propargylbenzylamine
  • Benzenemethanamine, N-methyl-N-2-propyn-1-yl-
  • N-Methyl-N-(2-propyn-1-yl)benzylamine
  • Pargyline USP/EP/BP
  • PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond)
  • Pargyline, 10 mM in DMSO
  • 555-57-7
  • C6H5CH2NCH3CH2C8801CH
  • C6H5CH2NCH3CH2CCH
  • Terminal
  • Organic Building Blocks
  • Building Blocks
  • Alkynes
  • PYRIDIUM
  • Organic Building Blocks
  • Terminal
  • Alkynes
  • Building Blocks
  • Chemical Synthesis