ChemicalBook > CAS DataBase List > 1-Boc-3-pyrrolidinecarbaldehyde

1-Boc-3-pyrrolidinecarbaldehyde

Product Name
1-Boc-3-pyrrolidinecarbaldehyde
CAS No.
59379-02-1
Chemical Name
1-Boc-3-pyrrolidinecarbaldehyde
Synonyms
TERT-BUTYL 3-FORMYLPYRROLIDINE-1-CARBOXYLATE;1-BOC-3-FORMYL-PYRROLIDINE;N-BOC-3-FORMYL PYRROLIDINE;1-Boc-3-formyl-pyrrolidine 95%;-Boc-3-pyrrolidinecarbaldehyde;1-BOC-3-PYRROLIDINECARBALDEHYDE;1-boc-3-pyrrolidineearbaldehyde;N-Boc-3-pyrrolidinecarbaldehyde;(+/-)-1-Boc-3-formylpyrrolidine;1-Boc-3- pyrrolidine formaldehyde
CBNumber
CB2436445
Molecular Formula
C10H17NO3
Formula Weight
199.25
MOL File
59379-02-1.mol
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1-Boc-3-pyrrolidinecarbaldehyde Property

Boiling point:
276.3±33.0 °C(Predicted)
Density 
1.148±0.06 g/cm3(Predicted)
refractive index 
1.47
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
-2.44±0.40(Predicted)
form 
Oil
color 
Colourless
InChI
InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h7-8H,4-6H2,1-3H3
InChIKey
DWLADVOODHZCFV-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C=O)C1
CAS DataBase Reference
59379-02-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-51-36-22
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6091
Product name
(±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
Packaging
1G
Price
$91
Updated
2025/07/31
TCI Chemical
Product number
B6091
Product name
(±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
Packaging
5G
Price
$364
Updated
2025/07/31
TRC
Product number
B665875
Product name
1-Boc-pyrrolidine-3-carboxaldehyde
Packaging
1g
Price
$140
Updated
2021/12/16
Usbiological
Product number
409037
Product name
1-Boc-pyrrolidine-3-carboxaldehyde
Packaging
10mg
Price
$312
Updated
2021/12/16
Usbiological
Product number
265685
Product name
1-Boc-3-formyl-pyrrolidine
Packaging
500mg
Price
$333
Updated
2021/12/16
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1-Boc-3-pyrrolidinecarbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow oil

Uses

1-Boc-pyrrolidine-3-carboxaldehyde is used in the preparation of tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.

Synthesis

114214-69-6

59379-02-1

General procedure for the synthesis of 1-Boc-3-pyrrolidinecarboxaldehyde from 1-Boc-3-hydroxymethylpyrrolidine: 1 kg of N-Boc-pyrrolidine-3-methanol was dissolved in 5 liters of dimethylsulfoxide (DMSO), and 2.14 kg of manganese dioxide was slowly added at room temperature. The reaction mixture was stirred at room temperature for about 24 hours to ensure complete reaction. Upon completion of the reaction, insoluble solids were removed by filtration and the filtrate was concentrated by rotary evaporator to remove solvent. Ultimately, N-Boc-pyrrolidine-3-carbaldehyde (920 g) was purified by reduced pressure distillation in 93% yield.

References

[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0036; 0041; 0042; 0046; 0047; 0048
[2] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 131
[3] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 159
[4] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[5] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789

1-Boc-3-pyrrolidinecarbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Boc-3-pyrrolidinecarbaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Career Henan Chemical Co
Product
1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

59379-02-1, 1-Boc-3-pyrrolidinecarbaldehydeRelated Search:

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