1-Boc-3-pyrrolidinecarbaldehyde

Product Name: 1-Boc-3-pyrrolidinecarbaldehyde
CAS No.: 59379-02-1
Chemical Name: 1-Boc-3-pyrrolidinecarbaldehyde
Synonyms: TERT-BUTYL 3-FORMYLPYRROLIDINE-1-CARBOXYLATE;1-BOC-3-FORMYL-PYRROLIDINE;N-BOC-3-FORMYL PYRROLIDINE;1-Boc-3-formyl-pyrrolidine 95%;-Boc-3-pyrrolidinecarbaldehyde;1-BOC-3-PYRROLIDINECARBALDEHYDE;1-boc-3-pyrrolidineearbaldehyde;N-Boc-3-pyrrolidinecarbaldehyde;(+/-)-1-Boc-3-formylpyrrolidine;1-Boc-3- pyrrolidine formaldehyde
CBNumber: CB2436445
Molecular Formula: C10H17NO3
Formula Weight: 199.25
MOL File: 59379-02-1.mol

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1-Boc-3-pyrrolidinecarbaldehyde Property

Boiling point:: 276.3±33.0 °C(Predicted)
Density: 1.148±0.06 g/cm3(Predicted)
refractive index: 1.47
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: -2.44±0.40(Predicted)
form: Oil
color: Colourless
InChI: InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h7-8H,4-6H2,1-3H3
InChIKey: DWLADVOODHZCFV-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C=O)C1
CAS DataBase Reference: 59379-02-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-51-36-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6091
Product name: (±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
Packaging: 1G
Price: $91
Updated: 2025/07/31

TCI Chemical

Product number: B6091
Product name: (±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
Packaging: 5G
Price: $364
Updated: 2025/07/31

TRC

Product number: B665875
Product name: 1-Boc-pyrrolidine-3-carboxaldehyde
Packaging: 1g
Price: $140
Updated: 2021/12/16

Usbiological

Product number: 409037
Product name: 1-Boc-pyrrolidine-3-carboxaldehyde
Packaging: 10mg
Price: $312
Updated: 2021/12/16

Usbiological

Product number: 265685
Product name: 1-Boc-3-formyl-pyrrolidine
Packaging: 500mg
Price: $333
Updated: 2021/12/16

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1-Boc-3-pyrrolidinecarbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow oil

Uses

1-Boc-pyrrolidine-3-carboxaldehyde is used in the preparation of tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.

Synthesis

114214-69-6

59379-02-1

General procedure for the synthesis of 1-Boc-3-pyrrolidinecarboxaldehyde from 1-Boc-3-hydroxymethylpyrrolidine: 1 kg of N-Boc-pyrrolidine-3-methanol was dissolved in 5 liters of dimethylsulfoxide (DMSO), and 2.14 kg of manganese dioxide was slowly added at room temperature. The reaction mixture was stirred at room temperature for about 24 hours to ensure complete reaction. Upon completion of the reaction, insoluble solids were removed by filtration and the filtrate was concentrated by rotary evaporator to remove solvent. Ultimately, N-Boc-pyrrolidine-3-carbaldehyde (920 g) was purified by reduced pressure distillation in 93% yield.

References

[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0036; 0041; 0042; 0046; 0047; 0048
[2] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 131
[3] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 159
[4] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[5] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789

1-Boc-3-pyrrolidinecarbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-pyrrolidinecarbaldehyde Suppliers

Americas 1 China 168 Europe 1 France 1 Germany 2 India 2 Japan 1 United Kingdom 3 United States 32 Global 211

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

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View Lastest Price from 1-Boc-3-pyrrolidinecarbaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Career Henan Chemical Co

Product: 1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

59379-02-1, 1-Boc-3-pyrrolidinecarbaldehydeRelated Search:

BUTYL OLEATE Tris(trimethylsilyl)phosphate Pyrrolidine N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Buprofezin tert-Butanol Methyl acrylate RESMETHRIN Dibutyl phthalate Povidone iodine Cyhalofop-butyl N-Vinyl-2-pyrrolidone tert-butyl 3-bromoazetidine-1-carboxylate 1-Boc-3-Cyanoazetidine N-Boc-3-Cyanopiperidine 4-N-Boc-2-cyanopiperidine METHYL-2-PYRROLIDONE

1-BOC-3-PYRROLIDINECARBALDEHYDE

3-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-3-FORMYL-PYRROLIDINE

1-BOC-PYRROLIDINE-3-CARBOXALDEHYDE

N-BOC-3-FORMYL PYRROLIDINE

TERT-BUTYL 3-FORMYLPYRROLIDINE-1-CARBOXYLATE

1-boc-3-pyrrolidineearbaldehyde

-Boc-3-pyrrolidinecarbaldehyde

1-Boc-3-formyl-pyrrolidine 95%

3-Formylpyrrolidine, N-BOC protected 98%

N-tert-Butoxycarbonyl-3-forMpyrrolidine

3-ForMyl-pyrrolidine-1-carboxylic acid tert-butyl ester, 95+%

1-Pyrrolidinecarboxylic acid, 3-forMyl-, 1,1-diMethylethyl ester

1-Boc-3-pyrrolidinecarbaldehyde 97% GC

1-(t-butoxycarbonyl)-3-pyrrolidinecarboxaldehyde

N-Boc-3-pyrrolidinecarbaldehyde

3-Formyl-pyrrolidine-1-carboxylic acid tert-butyl ester, >=97%

3-Formylpyrrolidine, N-BOC protected

(+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde

(+/-)-1-(tert-Butoxycarbonyl)-3-formylpyrrolidine

(+/-)-1-Boc-3-formylpyrrolidine

(+/-)-1-Boc-pyrrolidine-3-carboxaldehyde

(+/-)-3-Formylpyrrolidine-1-carboxylic Acid tert-Butyl Ester

(+/-)-tert-Butyl 3-Formylpyrrolidine-1-carboxylate

(±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde

1-Boc-3- pyrrolidine formaldehyde

1-Pyrrolidinecarboxylic acid, 3-formyl-, 1,1-dimethylethyl ester (9CI, ACI)

3-formyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)

1-Boc-pyrrolidine-3-carboxaldehyde, CAS 59379-02-1

1-Boc-3-pyrrolidinecarbaldehyde - [P13549]

59379-02-1

53979-02-1

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline