ChemicalBook > CAS DataBase List > METHYL 2,6-DIFLUOROBENZOATE

METHYL 2,6-DIFLUOROBENZOATE

Product Name
METHYL 2,6-DIFLUOROBENZOATE
CAS No.
13671-00-6
Chemical Name
METHYL 2,6-DIFLUOROBENZOATE
Synonyms
RARECHEM AL BF 0212;2,6-difluorobenzoate;METHYL 2,6-DIFLUOROBENZOATE;2,5-difluoro-3-methylbenzoate;Methyl2,6-difluorobenzoate98%;Methyl 2,6-difluorobenzoate 98%;Methyl 2,6-difluorobenzoate, 97%+;2,6-DIFLUOROBENZOIC ACID METHYL ESTER;2-(Methoxycarbonyl)-1,3-difluorobenzene;Benzoic acid, 2,6-difluoro-, Methyl ester
CBNumber
CB2438267
Molecular Formula
C8H6F2O2
Formula Weight
172.13
MOL File
13671-00-6.mol
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METHYL 2,6-DIFLUOROBENZOATE Property

Boiling point:
203-204 °C (lit.)
Density 
1.281 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.476(lit.)
Flash point:
203 °F
storage temp. 
Sealed in dry,Room Temperature
form 
fused solid
color 
White to off white
BRN 
1948618
CAS DataBase Reference
13671-00-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36-26/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
542636
Product name
Methyl 2,6-difluorobenzoate
Purity
97%
Packaging
25g
Price
$72.29
Updated
2025/07/31
TRC
Product number
M301815
Product name
Methyl 2,6-difluorobenzoate
Packaging
5g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC5075E
Product name
Methyl 2,6-difluorobenzoate
Purity
98%
Packaging
100g
Price
$80
Updated
2021/12/16
Matrix Scientific
Product number
002748
Product name
Methyl 2,6-difluorobenzoate
Purity
98%
Packaging
100g
Price
$74
Updated
2021/12/16
ChemScene
Product number
CS-M0553
Product name
Methyl 2,6-difluorobenzoate
Purity
99.87%
Packaging
100g
Price
$74
Updated
2021/12/16
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METHYL 2,6-DIFLUOROBENZOATE Chemical Properties,Usage,Production

Uses

Methyl 2,6-difluorobenzoate may be used in the synthesis of 9-hydroxy-13-(2,6-difluorophenyl)-3H-dibenzo[b,i]xanthen-3-one and 2,6-difluorobenzohydroxamic acid.

General Description

Methyl 2,6-difluorobenzoate is a fluorinated aromatic ester. It can be synthesized from 2,6-difluorobenzoic acid via esterification with methanol.

Synthesis

67-56-1

385-00-2

13671-00-6

GENERAL METHOD: A catalytic amount of concentrated H2SO4 (0.1 mmol) was added to a methanol (50 mL) solution of 2,6-difluorobenzoic acid (1.0 mmol) and the mixture was heated to reflux for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, saturated NaHCO3 solution (50 mL) was added to the reaction mixture to neutralize the acidic conditions, and then the product was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give pure methyl 2,6-difluorobenzoate.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 2, p. 233 - 241
[2] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 627 - 643
[3] Patent: WO2011/59610, 2011, A1. Location in patent: Page/Page column 101-102
[4] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 25
[5] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0147-0149

METHYL 2,6-DIFLUOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2,6-DIFLUOROBENZOATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 2,6-difluorobenzoate 13671-00-6
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-07
Career Henan Chemical Co
Product
METHYL 2,6-DIFLUOROBENZOATE 13671-00-6
Price
US $2.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100kg
Release date
2019-01-02

13671-00-6, METHYL 2,6-DIFLUOROBENZOATERelated Search:

METHYL PENTAFLUOROBENZOATE METHYL 2,6-DIFLUOROBENZOATE ETHYL PENTAFLUOROBENZOATE Methyl3,5-difluorobenzoate98%,METHYL 3,5-DIFLUOROBENZOATE,Methyl 3,5-difluorobenzoate 98% Methyl 4-bromo-2,6-difluorobenzoate Methyl 3,4-difluorobenzoate 97%,Methyl3,4-difluorobenzoate97%,METHYL 3,4-DIFLUOROBENZOATE METHYL 2,5-DIFLUOROBENZOATE METHYL 2,3-DIFLUOROBENZOATE METHYL 2,4-DIFLUOROBENZOATE 2,6-Difluorobenzoic acid 2 3 4 5 6-PENTAFLUOROBENZOIC ANHYDRIDE [5-(3,4-DICHLOROPHENYL)-3-ISOXAZOLYL]METHYL 2,6-DIFLUOROBENZENECARBOXYLATE 4-AZIDO-2,3,5,6-TETRAFLUOROBENZOIC ACID STP ESTER SODIUM SALT 2-[(5-CHLORO-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL)(METHYL)AMINO]ETHYL 2,6-DIFLUOROBENZENECARBOXYLATE (1-METHYL-3-PHENYL-5-[3-(TRIFLUOROMETHYL)PHENOXY]-1H-PYRAZOL-4-YL)METHYL 2,6-DIFLUOROBENZENECARBOXYLATE 2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)-1-(CYANOMETHYL)ETHYL 2,6-DIFLUOROBENZENECARBOXYLATE [4,5-DIBROMO-6-OXO-1(6H)-PYRIDAZINYL]METHYL 2,6-DIFLUOROBENZENECARBOXYLATE 2-(5-METHYL-7-OXO-4,7-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-6-YL)ETHYL 2,6-DIFLUOROBENZENECARBOXYLATE

  • 2,6-DIFLUOROBENZOIC ACID METHYL ESTER
  • METHYL 2,6-DIFLUOROBENZOATE
  • RARECHEM AL BF 0212
  • Methyl 2,6-difluorobenzoate 98%
  • Methyl2,6-difluorobenzoate98%
  • Benzoic acid, 2,6-difluoro-, Methyl ester
  • Methyl 2,6-difluorobenzoate, 97%+
  • 2,6-difluorobenzoate
  • 2-(Methoxycarbonyl)-1,3-difluorobenzene
  • 2,5-difluoro-3-methylbenzoate
  • Benzoic acid, 2,6-difluoro-, methyl ester (8CI, 9CI, ACI)
  • 2,6-difluoro-Benzoic acid methyl ester (8CI 9CI ACI)
  • 13671-00-6
  • Organic Building Blocks
  • Esters
  • Building Blocks
  • Carbonyl Compounds
  • C8 to C9
  • Aromatic Esters
  • C8 to C9
  • Carbonyl Compounds
  • Esters