Methyl 4-bromo-2,6-difluorobenzoate

Product Name: Methyl 4-bromo-2,6-difluorobenzoate
CAS No.: 773134-11-5
Chemical Name: Methyl 4-bromo-2,6-difluorobenzoate
Synonyms: CAS:773134-11-5;Methyl 4-bromo-2;4-bromo-2,6-difluorobenzoate;Methyl 4-bromo-2,6-difluorobenzene;4-Bromo-2,6-difluorobenzoate methyl ester;4-Bromo-2,6-difluorbenzoesaure-methylester;4-BroM-2,6-difluorbenzonic acid Methyl ester;Benzoic acid, 4-broMo-2,6-difluoro-, Methyl ester
CBNumber: CB4971799
Molecular Formula: C8H5BrF2O2
Formula Weight: 251.02
MOL File: 773134-11-5.mol

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Methyl 4-bromo-2,6-difluorobenzoate Property

Melting point:: 41-43℃
Boiling point:: 276.1±40.0 °C(Predicted)
Density: 1.652±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to light brown Solid
InChI: InChI=1S/C8H5BrF2O2/c1-13-8(12)7-5(10)2-4(9)3-6(7)11/h2-3H,1H3
InChIKey: JBXJLZRTTCGLNR-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=C(F)C=C(Br)C=C1F

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Safety

HazardClass: IRRITANT
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: M295965
Product name: Methyl4-bromo-2,6-difluorobenzoate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 057738
Product name: Methyl 4-bromo-2,6-difluorobenzoate
Purity: 95%
Packaging: 1g
Price: $26
Updated: 2021/12/16

ChemScene

Product number: CS-0018767
Product name: Methyl4-bromo-2,6-difluorobenzoate
Purity: 99.81%
Packaging: 25g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: Z0841
Product name: Methyl4-bromo-2,6-difluorobenzoate
Packaging: 5g
Price: $21
Updated: 2021/12/16

Apolloscientific

Product number: PC901514
Product name: Methyl4-bromo-2,6-difluorobenzoate
Purity: 98%
Packaging: 5g
Price: $58
Updated: 2021/12/16

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Methyl 4-bromo-2,6-difluorobenzoate Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

Methyl 4-bromo-2,6-difluorobenzoate is a pharmaceutical intermediate compound used in the preparation of contraceptive compositions.

Synthesis

183065-68-1

18107-18-1

773134-11-5

(a) Synthesis of methyl 4-bromo-2,6-difluorobenzoate. At room temperature, (trimethylmethylsilyl) diazomethane (2.0 M ether solution, 15.0 mL, 30.0 mmol) was slowly added dropwise through a charging funnel to a mixture of dichloromethane (32.0 mL) and methanol (8.0 mL) of 4-bromo-2,6-difluorobenzoic acid (5.0 g, 21.10 mmol). The reaction mixture was stirred for 15 min and then concentrated under reduced pressure to afford methyl 4-bromo-2,6-difluorobenzoate (5.30 g, 21.11 mmol, 100% yield) as a clarified light orange oil. The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 7.17 (dd, J = 8.8, 1.5 Hz, 2H), 3.95 (s, 3H). Mass spectrometry (ES+) analysis showed m/e 251/253 [M + H]+.

References

[1] Patent: US2010/305133, 2010, A1. Location in patent: Page/Page column 34
[2] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 211; 212

Methyl 4-bromo-2,6-difluorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-bromo-2,6-difluorobenzoate Suppliers

China 121 India 1 United States 11 Global 133

Hefei Mokai Pharmaceutical Technology Co., Ltd

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View Lastest Price from Methyl 4-bromo-2,6-difluorobenzoate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 4-bromo-2,6-difluorobenzoate 773134-11-5
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-07

Career Henan Chemical Co

Product: Methyl 4-bromo-2,6-difluorobenzoate 773134-11-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-24

773134-11-5, Methyl 4-bromo-2,6-difluorobenzoateRelated Search:

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4-Bromo-2,6-difluorbenzoesaure-methylester

4-BroM-2,6-difluorbenzonic acid Methyl ester

Benzoic acid, 4-broMo-2,6-difluoro-, Methyl ester

4-bromo-2,6-difluorobenzoate

4-Bromo-2,6-difluorobenzoate methyl ester

Methyl 4-bromo-2

Methyl 4-bromo-2,6-difluorobenzene

CAS:773134-11-5

773134-11-5

Fluorine series