METHYL 4-BROMO-3-HYDROXYBENZOATE

Product Name: METHYL 4-BROMO-3-HYDROXYBENZOATE
CAS No.: 106291-80-9
Chemical Name: METHYL 4-BROMO-3-HYDROXYBENZOATE
Synonyms: SW 1573[SW-1573,SW1573];METHYL 4-BROMO-3-HYDROXYBENZOATE;Methyl 3-hydroxy-4-bromobenzoate;2-Bromo-5-(methoxycarbonyl)phenol;Methyl4-Bromo-3-hydroxybenzoate>Methyl 4-bromo-3-hydroxybenzoate 98%;Methyl 4-Bromo-3-hydroxybenzoate, >=98%;4-BROMO-3-HYDROXY-BENZOIC ACIDMETHYL ESTER;Benzoic acid, 4-bromo-3-hydroxy-, methyl ester;Benzoic acid, 4-bromo-3-hydroxy-, methyl ester (9CI, ACI)
CBNumber: CB1377266
Molecular Formula: C8H7BrO3
Formula Weight: 231.04
MOL File: 106291-80-9.mol

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METHYL 4-BROMO-3-HYDROXYBENZOATE Property

Melting point:: 121-125
Boiling point:: 318.0±22.0 °C(Predicted)
Density: 1.627±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Dichloromethane, Methanol
form: Burgandy Color
pka: 7.61±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C8H7BrO3/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4,10H,1H3
InChIKey: VYOFPLOREOHCDP-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(Br)C(O)=C1
CAS DataBase Reference: 106291-80-9

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Safety

Hazard Codes: Xi
Hazard Note: Irritant/Keep Cold
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2246
Product name: Methyl 4-Bromo-3-hydroxybenzoate
Purity: >98.0%(GC)
Packaging: 1g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: M2246
Product name: Methyl 4-Bromo-3-hydroxybenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $205
Updated: 2025/07/31

TRC

Product number: B684675
Product name: 4-Bromo-3-hydroxybenzoicAcidMethylEster
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR9408
Product name: Methyl 4-bromo-3-hydroxybenzoate
Purity: 97%
Packaging: 1g
Price: $32
Updated: 2021/12/16

Matrix Scientific

Product number: 075354
Product name: Methyl 4-bromo-3-hydroxybenzoate
Purity: 95+%
Packaging: 1g
Price: $50
Updated: 2021/12/16

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METHYL 4-BROMO-3-HYDROXYBENZOATE Chemical Properties,Usage,Production

Chemical Properties

Burgandy Color

Uses

Methyl 4-BroMo-3-hydroxybenzoate is a reactant used in the preparation of selective inhibitors.

Synthesis

67-56-1

14348-38-0

106291-80-9

Step A. Synthesis of methyl 4-bromo-3-hydroxybenzoate: To a solution of methanol (100 mL) containing 4-bromo-3-hydroxybenzoic acid (30 mmol) was slowly added concentrated sulfuric acid (2.6 mL). The reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, followed by the slow addition of saturated aqueous sodium carbonate to adjust the pH to 7. The reaction solution was concentrated to one-third of the original volume and diluted with an appropriate amount of water. Extraction was carried out with ethyl acetate and the organic phases were combined. The organic phase was washed with water and saturated saline in turn and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a white solid product, methyl 4-bromo-3-hydroxybenzoate, 6.15 g (89% yield) with a melting point of 205 °C (literature value: 130-132 °C).

References

[1] Chemical Communications, 2013, vol. 49, # 10, p. 990 - 992
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4863 - 4867
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3540 - 3560
[4] Patent: US2006/199806, 2006, A1. Location in patent: Page/Page column 23
[5] Patent: WO2005/115996, 2005, A1. Location in patent: Page/Page column 66

METHYL 4-BROMO-3-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-3-HYDROXYBENZOATE Suppliers

Americas 1 Australia 1 Canada 2 China 140 Europe 1 France 1 India 17 Japan 2 United Kingdom 3 United States 33 Global 201

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View Lastest Price from METHYL 4-BROMO-3-HYDROXYBENZOATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl 4-bromo-3-hydroxybenzoate 106291-80-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-08

Career Henan Chemical Co

Product: METHYL 4-BROMO-3-HYDROXYBENZOATE 106291-80-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

106291-80-9, METHYL 4-BROMO-3-HYDROXYBENZOATERelated Search:

METHYL 4-BROMO-3-METHOXYBENZOATE Methyl 4-BroMo-5-chloro-2-furoate Methyl 4-bromo-3-methylbenzoate METHYL 4-BROMO-3-FLUOROBENZOATE 98 TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE METHYL 3,5-DIBROMO-4-HYDROXYBENZOATE METHYL 3,5-DIBROMO-2-HYDROXYBENZOATE TERT-BUTYL 4-BROMO-3-METHOXYBENZOATE 98 METHYL 3-(BENZYLOXY)-4-BROMOBENZOATE 98 METHYL 4-BROMO-3-HYDROXYBENZOATE 4-BROMO-3-HYDROXYBENZOIC ACID Methyl 3-hydroxybenzoate TERT-BUTYL 4-BROMO-3,5-DIHYDROXYBENZOATE ETHYL 4-BROMO-3-HYDROXYBENZOATE TERT-BUTYL 4-BROMO-3,5-DIMETHOXYBENZOATE 4-BROMO-3,5-DIMETHOXYBENZOIC ACID METHYL ESTER methyl 4-bromo-3,5-dihydroxy-benzoate METHYL 4-BROMO-2-HYDROXYBENZOATE

Methyl 4-bromo-3-hydroxybenzoate 98%

4-BROMO-3-HYDROXY-BENZOIC ACIDMETHYL ESTER

METHYL 4-BROMO-3-HYDROXYBENZOATE

2-Bromo-5-(methoxycarbonyl)phenol

Methyl 3-hydroxy-4-bromobenzoate

Methyl 4-Bromo-3-hydroxybenzoate, >=98%

SW 1573[SW-1573,SW1573]

Methyl4-Bromo-3-hydroxybenzoate&gt

Benzoic acid, 4-bromo-3-hydroxy-, methyl ester

Benzoic acid, 4-bromo-3-hydroxy-, methyl ester (9CI, ACI)

106291-80-9

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