ChemicalBook > CAS DataBase List > METHYL 4-BROMO-3-HYDROXYBENZOATE
METHYL 4-BROMO-3-HYDROXYBENZOATE
- Product Name
- METHYL 4-BROMO-3-HYDROXYBENZOATE
- CAS No.
- 106291-80-9
- Chemical Name
- METHYL 4-BROMO-3-HYDROXYBENZOATE
- Synonyms
- SW 1573[SW-1573,SW1573];METHYL 4-BROMO-3-HYDROXYBENZOATE;Methyl 3-hydroxy-4-bromobenzoate;2-Bromo-5-(methoxycarbonyl)phenol;Methyl4-Bromo-3-hydroxybenzoate>Methyl 4-bromo-3-hydroxybenzoate 98%;Methyl 4-Bromo-3-hydroxybenzoate, >=98%;4-BROMO-3-HYDROXY-BENZOIC ACIDMETHYL ESTER;Benzoic acid, 4-bromo-3-hydroxy-, methyl ester;Benzoic acid, 4-bromo-3-hydroxy-, methyl ester (9CI, ACI)
- CBNumber
- CB1377266
- Molecular Formula
- C8H7BrO3
- Formula Weight
- 231.04
- MOL File
- 106291-80-9.mol
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METHYL 4-BROMO-3-HYDROXYBENZOATE Property
- Melting point:
- 121-125
- Boiling point:
- 318.0±22.0 °C(Predicted)
- Density
- 1.627±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Dichloromethane, Methanol
- form
- Burgandy Color
- pka
- 7.61±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C8H7BrO3/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4,10H,1H3
- InChIKey
- VYOFPLOREOHCDP-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(Br)C(O)=C1
- CAS DataBase Reference
- 106291-80-9
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Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2918290090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- M2246
- Product name
- Methyl 4-Bromo-3-hydroxybenzoate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $61
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2246
- Product name
- Methyl 4-Bromo-3-hydroxybenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $205
- Updated
- 2025/07/31
TRC
- Product number
- B684675
- Product name
- 4-Bromo-3-hydroxybenzoicAcidMethylEster
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 075354
- Product name
- Methyl 4-bromo-3-hydroxybenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR9408
- Product name
- Methyl 4-bromo-3-hydroxybenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $82
- Updated
- 2021/12/16
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METHYL 4-BROMO-3-HYDROXYBENZOATE Chemical Properties,Usage,Production
Chemical Properties
Burgandy Color
Uses
Methyl 4-BroMo-3-hydroxybenzoate is a reactant used in the preparation of selective inhibitors.
Synthesis
67-56-1
14348-38-0
106291-80-9
Step A. Synthesis of methyl 4-bromo-3-hydroxybenzoate: To a solution of methanol (100 mL) containing 4-bromo-3-hydroxybenzoic acid (30 mmol) was slowly added concentrated sulfuric acid (2.6 mL). The reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, followed by the slow addition of saturated aqueous sodium carbonate to adjust the pH to 7. The reaction solution was concentrated to one-third of the original volume and diluted with an appropriate amount of water. Extraction was carried out with ethyl acetate and the organic phases were combined. The organic phase was washed with water and saturated saline in turn and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a white solid product, methyl 4-bromo-3-hydroxybenzoate, 6.15 g (89% yield) with a melting point of 205 °C (literature value: 130-132 °C).
References
[1] Chemical Communications, 2013, vol. 49, # 10, p. 990 - 992
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4863 - 4867
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3540 - 3560
[4] Patent: US2006/199806, 2006, A1. Location in patent: Page/Page column 23
[5] Patent: WO2005/115996, 2005, A1. Location in patent: Page/Page column 66
METHYL 4-BROMO-3-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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METHYL 4-BROMO-3-HYDROXYBENZOATE Suppliers
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View Lastest Price from METHYL 4-BROMO-3-HYDROXYBENZOATE manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Methyl 4-bromo-3-hydroxybenzoate 106291-80-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
Career Henan Chemical Co
- Product
- METHYL 4-BROMO-3-HYDROXYBENZOATE 106291-80-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20
106291-80-9, METHYL 4-BROMO-3-HYDROXYBENZOATERelated Search:
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