METHYL 4-BROMO-2-HYDROXYBENZOATE

Product Name: METHYL 4-BROMO-2-HYDROXYBENZOATE
CAS No.: 22717-56-2
Chemical Name: METHYL 4-BROMO-2-HYDROXYBENZOATE
Synonyms: Methyl 4-Bromosalicylate;METHYL 4-BROMO-2-HYDROXYBENZOATE;4-Bromo-2-hydroxybenzoic acid methyl ester;Methyl 4-bromo-2-hydroxybenzenecarboxylate;Benzoic acid, 4-bromo-2-hydroxy-, methyl ester
CBNumber: CB9324473
Molecular Formula: C8H7BrO3
Formula Weight: 231.04
MOL File: 22717-56-2.mol

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METHYL 4-BROMO-2-HYDROXYBENZOATE Property

Melting point:: 41-42°
Boiling point:: 284.7±20.0 °C(Predicted)
Density: 1.627±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.79±0.10(Predicted)
form: solid
Appearance: White to yellow Solid
InChI: InChI=1S/C8H7BrO3/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4,10H,1H3
InChIKey: JEMVEVUWSJXZMX-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(Br)C=C1O

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Safety

HazardClass: IRRITANT
HS Code: 2916310090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H336May cause drowsiness or dizziness

H360May damage fertility or the unborn child

H371May cause damage to organs

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P331Do NOT induce vomiting.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M296498
Product name: Methyl4-Bromo-2-hydroxybenzoate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M296498
Product name: Methyl4-Bromo-2-hydroxybenzoate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB66855
Product name: 4-Bromo-2-hydroxybenzoic acid methyl ester
Packaging: 1g
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR400066
Product name: Methyl4-bromo-2-hydroxybenzoate
Packaging: 1g
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-9-14
Product name: Methyl 4-bromo-2-hydroxybenzoate
Packaging: 1g
Price: $29
Updated: 2021/12/16

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METHYL 4-BROMO-2-HYDROXYBENZOATE Chemical Properties,Usage,Production

Synthesis

67-56-1

1666-28-0

22717-56-2

2-Hydroxy-4-bromobenzoic acid (5.0 g, 23.1 mmol) was dissolved in 20 mL of anhydrous methanol and 1.7 mL of concentrated sulfuric acid was added slowly. The reaction mixture was heated and refluxed under stirring for 24 hours. Upon completion of the reaction, the reaction solution was poured into ice water and concentrated by rotary evaporator to remove methanol. Subsequently, extraction was carried out with ethyl acetate (EA) and the organic phase was washed with saturated sodium bicarbonate (NaHCO3) solution and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated to afford methyl 2-hydroxy-4-bromobenzoate (5.31 g) as a reddish brown solid, and the product was used directly in the next reaction without further purification.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3228 - 3241
[2] Patent: US2016/221997, 2016, A1. Location in patent: Paragraph 0245; 0246; 0247
[3] Patent: WO2016/115282, 2016, A1. Location in patent: Page/Page column 76
[4] Patent: WO2015/163485, 2015, A1. Location in patent: Paragraph 0372
[5] Tetrahedron Letters, 2016, vol. 57, # 48, p. 5301 - 5303

METHYL 4-BROMO-2-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-2-HYDROXYBENZOATE Suppliers

China 109 India 1 Switzerland 1 United Kingdom 5 United States 9 Global 125

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View Lastest Price from METHYL 4-BROMO-2-HYDROXYBENZOATE manufacturers

Career Henan Chemical Co

Product: METHYL 4-BROMO-2-HYDROXYBENZOATE 22717-56-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

22717-56-2, METHYL 4-BROMO-2-HYDROXYBENZOATERelated Search:

METHYL 4-BROMO-2-METHOXYBENZOATE 98 Methyl 4-broMo-2-fluoro-6-hydroxybenzoate 4-BROMO-2-CHLOROBENZOIC ACID METHYL ESTER Methyl 4-bromo-2-fluoro-6-methylbenzoate Methyl 4-bromo-2-fluorobenzoate Methyl 4-bromo-2-cyanobenzoate VUWUSIPTJCXEGH-UHFFFAOYSA-N methyl 4-bromo-2-formylbenzoate 4-Bromo-2-chloro-6-methyl-benzoic acid methyl ester BENZOIC ACID, 4-AMINO-2-BROMO-, METHYL ESTER METHYL 4-BROMO-3-FLUOROBENZOATE 98 4-BroMo-2-iodo-benzoic acid Methyl ester METHYL 4-BROMO-3-HYDROXYBENZOATE Methyl 4-bromo-3-methylbenzoate Methyl 4-bromobenzoate METHYL 4-BROMO-3-METHOXYBENZOATE BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER Methyl 4-bromo-2,6-difluorobenzoate

METHYL 4-BROMO-2-HYDROXYBENZOATE

Methyl 4-bromo-2-hydroxybenzenecarboxylate

4-Bromo-2-hydroxybenzoic acid methyl ester

Benzoic acid, 4-bromo-2-hydroxy-, methyl ester

Methyl 4-Bromosalicylate

22717-56-2

Aromatic Esters

Acids & Esters

Bromine Compounds

Phenols