Methyl 4-amino-2-bromobenzoate
- Product Name
- Methyl 4-amino-2-bromobenzoate
- CAS No.
- 98545-64-3
- Chemical Name
- Methyl 4-amino-2-bromobenzoate
- Synonyms
- methyl-2-bromo-4-aminobenzoate;Methyl 4-aMino-2-broMobenzoate;4-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER;BENZOIC ACID, 4-AMINO-2-BROMO-, METHYL ESTER
- CBNumber
- CB92594311
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 98545-64-3.mol
Methyl 4-amino-2-bromobenzoate Property
- Melting point:
- 94 °C
- Boiling point:
- 345.2±22.0 °C(Predicted)
- Density
- 1.578±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 1.39±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M328473
- Product name
- Methyl4-amino-2-bromobenzoate
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- M328473
- Product name
- Methyl4-amino-2-bromobenzoate
- Packaging
- 2.5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- FA71583
- Product name
- 4-Amino-2-bromobenzoic acid methyl ester
- Packaging
- 25g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- HCH0132447
- Product name
- 4-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.82
- Updated
- 2021/12/16
- Product number
- V9914
- Product name
- Methyl4-amino-2-bromobenzoate
- Packaging
- 25g
- Price
- $725
- Updated
- 2021/12/16
Methyl 4-amino-2-bromobenzoate Chemical Properties,Usage,Production
Uses
Methyl 4-amino-2-bromobenzoate is an organic compound that is commonly used as a synthetic intermediate, especially in the pharmaceutical industry, for the synthesis of biologically active compounds.
Synthesis
100959-22-6
98545-64-3
General procedure for the synthesis of methyl 4-amino-2-bromobenzoate from methyl 2-bromo-4-nitrobenzoate: To a solution of methyl 2-bromo-4-nitrobenzoate (4.5 g, 17.0 mmol) in ethyl acetate (100 mL) was added stannous chloride dihydrate (38.3 g, 0.17 mol). The reaction mixture was heated to reflux and stirred for 4 hours. Upon completion of the reaction, the mixture was poured into a mixture of saturated sodium bicarbonate solution (500 mL) and ethyl acetate (370 mL). The organic layer was separated, washed with saturated brine (300 mL) and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by silica gel column chromatography to afford methyl 4-amino-2-bromobenzoate as a solid (3.68 g, 94.2% yield).1H NMR (400 MHz, CDCl3): δ 7.75 (d, J = 8.5 Hz, 1H), 6.92 (d, J = 2.2 Hz, 1H), 6.57 (dd, J = 8.5,2.2 Hz, 1H), 4.04 (brs, 2H) and 3.86 (s, 3H) ppm; melting point: 96-98 °C.
References
[1] Organic Letters, 2013, vol. 15, # 13, p. 3234 - 3237
[2] Chinese Chemical Letters, 2011, vol. 22, # 12, p. 1411 - 1414
[3] European Journal of Medicinal Chemistry, 2014, vol. 81, p. 59 - 75
[4] Acad. romine Stud. Cerc. Chim., 1956, vol. 4, p. 175,178
[5] Patent: WO2012/93101, 2012, A1. Location in patent: Page/Page column 236-237
Methyl 4-amino-2-bromobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-amino-2-bromobenzoate Suppliers
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 0519-85252752 15366845260
- Fax
- 86-0519-85683352
- taihuaren@vip.163.com
- Country
- China
- ProdList
- 1125
- Advantage
- 58
- Tel
- 13912302692
- Fax
- 0519-88064678
- sales@anxuanchem.com
- Country
- China
- ProdList
- 4828
- Advantage
- 58
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 0570-3081766 18357083060
- Fax
- 0570-3072337
- sales@qzamkbio.com
- Country
- China
- ProdList
- 1046
- Advantage
- 55