ChemicalBook > CAS DataBase List > Methyl 4-amino-2-bromobenzoate

Methyl 4-amino-2-bromobenzoate

Product Name: Methyl 4-amino-2-bromobenzoate
CAS No.: 98545-64-3
Chemical Name: Methyl 4-amino-2-bromobenzoate
Synonyms: methyl-2-bromo-4-aminobenzoate;Methyl 4-aMino-2-broMobenzoate;4-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER;BENZOIC ACID, 4-AMINO-2-BROMO-, METHYL ESTER
CBNumber: CB92594311
Molecular Formula: C8H8BrNO2
Formula Weight: 230.06
MOL File: 98545-64-3.mol

Less

Methyl 4-amino-2-bromobenzoate Property

Melting point:: 94 °C
Boiling point:: 345.2±22.0 °C(Predicted)
Density: 1.578±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 1.39±0.10(Predicted)
Appearance: Light yellow to light brown Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: M328473
Product name: Methyl4-amino-2-bromobenzoate
Packaging: 1g
Price: $165
Updated: 2021/12/16

TRC

Product number: M328473
Product name: Methyl4-amino-2-bromobenzoate
Packaging: 2.5g
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA71583
Product name: 4-Amino-2-bromobenzoic acid methyl ester
Packaging: 25g
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0132447
Product name: 4-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $503.82
Updated: 2021/12/16

AK Scientific

Product number: V9914
Product name: Methyl4-amino-2-bromobenzoate
Packaging: 25g
Price: $725
Updated: 2021/12/16

Less

Methyl 4-amino-2-bromobenzoate Chemical Properties,Usage,Production

Uses

Methyl 4-amino-2-bromobenzoate is an organic compound that is commonly used as a synthetic intermediate, especially in the pharmaceutical industry, for the synthesis of biologically active compounds.

Synthesis

100959-22-6

98545-64-3

General procedure for the synthesis of methyl 4-amino-2-bromobenzoate from methyl 2-bromo-4-nitrobenzoate: To a solution of methyl 2-bromo-4-nitrobenzoate (4.5 g, 17.0 mmol) in ethyl acetate (100 mL) was added stannous chloride dihydrate (38.3 g, 0.17 mol). The reaction mixture was heated to reflux and stirred for 4 hours. Upon completion of the reaction, the mixture was poured into a mixture of saturated sodium bicarbonate solution (500 mL) and ethyl acetate (370 mL). The organic layer was separated, washed with saturated brine (300 mL) and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by silica gel column chromatography to afford methyl 4-amino-2-bromobenzoate as a solid (3.68 g, 94.2% yield).1H NMR (400 MHz, CDCl3): δ 7.75 (d, J = 8.5 Hz, 1H), 6.92 (d, J = 2.2 Hz, 1H), 6.57 (dd, J = 8.5,2.2 Hz, 1H), 4.04 (brs, 2H) and 3.86 (s, 3H) ppm; melting point: 96-98 °C.

References

[1] Organic Letters, 2013, vol. 15, # 13, p. 3234 - 3237
[2] Chinese Chemical Letters, 2011, vol. 22, # 12, p. 1411 - 1414
[3] European Journal of Medicinal Chemistry, 2014, vol. 81, p. 59 - 75
[4] Acad. romine Stud. Cerc. Chim., 1956, vol. 4, p. 175,178
[5] Patent: WO2012/93101, 2012, A1. Location in patent: Page/Page column 236-237

Methyl 4-amino-2-bromobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methyl 4-amino-2-bromobenzoate Suppliers

China 66 India 1 United Kingdom 1 United States 6 Global 74

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Xinyanhe Pharmatech Co.,Ltd

Tel: 0519-85252752 15366845260
Fax: 86-0519-85683352
Email: taihuaren@vip.163.com
Country: China
ProdList: 1124
Advantage: 58

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 0512-0512-52358471 17715136450
Fax: 05125235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 12127
Advantage: 58

Quzhou AMK BioTech Co., Ltd

Tel: 0570-3081766 18357083060
Fax: 0570-3072337
Email: sales@qzamkbio.com
Country: China
ProdList: 1047
Advantage: 55

Shanghai Brain Biotechnology Co., Ltd.

Tel: 13564638271
Fax: 021-68948280
Email: shhjiang1977@163.com
Country: China
ProdList: 2987
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Suzhou Xiya Pharmaceutical Co., Ltd.

Tel: 0512-87819718 18912655635
Email: 2587879032@qq.com
Country: China
ProdList: 1403
Advantage: 58

Zhengzhou Ruke Biological Co., Ltd.

Tel: 15981811963
Fax: QQ：1410472904
Email: 1410472904@qq.com
Country: China
ProdList: 5825
Advantage: 58

Jinan Liheng Biotechnology Co., Ltd.

Tel: 0531-18763987518 18763987518
Email: levi@lihengpharm.com
Country: China
ProdList: 1793
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Fuxin Crest Biotechnology Co. Ltd.

Tel: 13062833949
Fax: QQ: 2073772974
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 853
Advantage: 58

Nanjing Easichem Co. ltd.

Tel: 18061688856
Email: easichem@126.com
Country: China
ProdList: 477
Advantage: 58

Xinyi Kangda Biological Technology Co., Ltd.

Tel: 13013943931 15152133928
Email: xinyikangda@163.com
Country: China
ProdList: 610
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9941
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Xinyi Huaju Pharmaceutical Technology Co., Ltd.

Tel: 13761372795
Email: huajupharm@163.com
Country: China
ProdList: 806
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Shanghai Hongju Pharmaceutical Technology Co., LTD

Tel: 18001895509
Fax: QQ2934193566;
Email: 986383309@qq.com
Country: China
ProdList: 2680
Advantage: 58

Krain Pharmaceutical Technology CO.,Ltd

Tel: 18252089365
Email: Krain_kerun@163.com
Country: China
ProdList: 2507
Advantage: 58

Shanghai Xuanlin Pharmaceutical Technology Co., Ltd

Tel: 13955239259
Fax: QQ3450014153 ;
Email: 3295742260@qq.com
Country: China
ProdList: 976
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Huida Medical Technology (Shanghai) Co., LTD

Tel: 15173502222
Fax: QQ:200761233
Email: 524226@qq.com
Country: China
ProdList: 606
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Hubei Hannuo Pharmaceutical Technology Co., Ltd

Tel: 18662190603
Email: 437347250@qq.com
Country: China
ProdList: 7325
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Shanghai Yanbang Pharmaceutical Technology Co., Ltd

Tel: 15618536883
Email: 1228181347@qq.com
Country: China
ProdList: 7951
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 19353112242
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

chemfish tokyo co.,ltd

Tel: 0731-0731-85521272 18570329630
Email: sales@chemfish.com
Country: China
ProdList: 3027
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd.

Tel: 18560864701
Email: 643971@qq.com
Country: China
ProdList: 6098
Advantage: 58

Shaanxi Gulliver Biotechnology Research Co., Ltd

Tel: 0917-77953337 18409274651
Email: 2823986536@qq.com
Country: China
ProdList: 2960
Advantage: 58

98545-64-3, Methyl 4-amino-2-bromobenzoateRelated Search:

2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) methyl 4-amino-2-chloro-5-iodobenzoate METHYL 4-AMINO-3,5-DICHLOROBENZOATE Methyl 4-amino-2-methoxybenzoate Methyl 4-amino-2-cyanobenzoate Methyl 4-aMino-3,5-difluorobenzoate Methyl 4-amino-2-chlorobenzoate Methyl-4-amino-3-fluorobenzoate METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE METHYL 4-AMINO-2,3-DIFLUOROBENZOATE METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE METHYL 4-AMINO-3-CHLOROBENZOATE Methyl 4-amino-3-(trifluoromethoxy)benzoate Methyl 2,6-dichloro-4-aminobenzoate Methyl 4-amino-3-bromobenzoate Methyl 4-aMino-2,6-diMethylbenzoate METHYL 4-BROMO-2-HYDROXYBENZOATE METHYL 4-BROMO-3-FLUOROBENZOATE 98

BENZOIC ACID, 4-AMINO-2-BROMO-, METHYL ESTER

4-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER

Methyl 4-aMino-2-broMobenzoate

methyl-2-bromo-4-aminobenzoate

98545-64-3