Methyl 4-amino-3-(trifluoromethoxy)benzoate

Product Name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
CAS No.: 457097-93-7
Chemical Name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Synonyms: Methyl 4-amino-3-(trifluoromethoxy)benzoate;3-trifluoromethoxy-4-aminobenzoate methyl ester;Benzoic acid, 4-amino-3-(trifluoromethoxy)-, methyl ester
CBNumber: CB12688652
Molecular Formula: C9H8F3NO3
Formula Weight: 235.16
MOL File: 457097-93-7.mol

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Methyl 4-amino-3-(trifluoromethoxy)benzoate Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Appearance: Yellow to brown Solid

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Safety

HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 076963
Product name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Packaging: 5.00g
Price: $90
Updated: 2026/05/18

Matrix Scientific

Product number: 076963
Product name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Packaging: 10.00g
Price: $144
Updated: 2026/05/18

Matrix Scientific

Product number: 076963
Product name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Packaging: 25.00g
Price: $325
Updated: 2026/05/18

Synthonix

Product number: M51482
Product name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Purity: 95+%
Packaging: 250mg
Price: $28
Updated: 2026/05/06

Synthonix

Product number: M51482
Product name: Methyl 4-amino-3-(trifluoromethoxy)benzoate
Purity: 95+%
Packaging: 1g
Price: $34
Updated: 2026/05/06

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Methyl 4-amino-3-(trifluoromethoxy)benzoate Chemical Properties,Usage,Production

Synthesis

175278-22-5

67-56-1

457097-93-7

Thionyl chloride (2.68 g, 0.023 mol) was slowly added dropwise to methanol (12 mL) via a syringe at -5 °C, ensuring that the reaction temperature did not exceed -4 °C. After the dropwise addition was completed, the reaction mixture was stirred continuously at -5 °C or lower for 1 hour. Subsequently, 4-amino-3-(trifluoromethoxy)benzoic acid (0.5 g, 0.003 mol) [Alfa Aesar] was added all at once. The reaction mixture was transferred to ambient temperature and stirred for 3 days. After completion of the reaction, the solvent was removed by vacuum concentration. Water (10 mL) was added to the residue and sodium bicarbonate (0.46 g, 5.4 mmol) was added all at once and stirred at ambient temperature for 30 min. The mixture was extracted several times using ethyl acetate. The organic phases were combined, dried with sodium sulfate, filtered and concentrated in vacuum to afford methyl 4-amino-3-(trifluoromethoxy)benzoate 1.02 g (96.2% yield), which was initially a reddish oily material, and gradually transformed to a brown solid after cooling. Mass Spectrometry (MS): m/z 236.1 (MH+). 1H NMR (500MHz, DMSO-d6) data: δ3.771 (s, 3H), 6.329 (s, 2H), 6.834 (d, 1H), 7.6181 (s, 1H), 7.655 (dd, 1H).

References

[1] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 92
[2] Patent: US2015/175557, 2015, A1. Location in patent: Paragraph 0300
[3] Patent: EP2017263, 2009, A1. Location in patent: Page/Page column 213
[4] Patent: US2013/115194, 2013, A1. Location in patent: Paragraph 0335
[5] Patent: US2013/287731, 2013, A1. Location in patent: Paragraph 0284; 0285

Methyl 4-amino-3-(trifluoromethoxy)benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-amino-3-(trifluoromethoxy)benzoate Suppliers

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457097-93-7, Methyl 4-amino-3-(trifluoromethoxy)benzoateRelated Search:

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Methyl 4-amino-3-(trifluoromethoxy)benzoate

Benzoic acid, 4-amino-3-(trifluoromethoxy)-, methyl ester

3-trifluoromethoxy-4-aminobenzoate methyl ester

457097-93-7