METHYL 4-AMINO-3,5-DICHLOROBENZOATE
- Product Name
- METHYL 4-AMINO-3,5-DICHLOROBENZOATE
- CAS No.
- 41727-48-4
- Chemical Name
- METHYL 4-AMINO-3,5-DICHLOROBENZOATE
- Synonyms
- METHYL 4-AMINO-3,5-DICHLOROBENZOATE;4-Amino-3,5-dichlorobenzoic acid methyl ester;Benzoicacid, 4-amino-3,5-dichloro-, methyl ester
- CBNumber
- CB5149847
- Molecular Formula
- C8H7Cl2NO2
- Formula Weight
- 220.05
- MOL File
- 41727-48-4.mol
METHYL 4-AMINO-3,5-DICHLOROBENZOATE Property
- Melting point:
- 79-81
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9587AF
- Product name
- Methyl4-amino-3,5-dichlorobenzoate
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4658-5-00
- Product name
- Methyl 4-amino-3,5-dichlorobenzoate
- Purity
- 97%
- Packaging
- 5G
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 9587AF
- Product name
- Methyl4-amino-3,5-dichlorobenzoate
- Packaging
- 10g
- Price
- $243
- Updated
- 2021/12/16
- Product number
- J52072
- Product name
- Methyl4-amino-3,5-dichlorobenzoate
- Packaging
- 25g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- HCH0014209
- Product name
- METHYL 4-AMINO-3,5-DICHLOROBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.26
- Updated
- 2021/12/16
METHYL 4-AMINO-3,5-DICHLOROBENZOATE Chemical Properties,Usage,Production
Synthesis
67-56-1
56961-25-2
41727-48-4
General procedure for the synthesis of methyl 4-amino-3,5-dichlorobenzoate from methanol and 4-amino-3,5-dichlorobenzoic acid: Thionyl chloride (2.14 g, 0.018 mol) was slowly added dropwise to methanol (10 mL) via a syringe under the condition of -3 to -4 °C. The reaction temperature was controlled not to exceed -1.1 °C during the dropwise addition, and the time of the dropwise addition was about 35 min. After the dropwise addition, the reaction mixture was stirred at 0 °C or lower for 1 hour. Subsequently, 4-amino-3,5-dichlorobenzoic acid (0.75 g, 3.6 mmol) [ACROS Organics] was added in a single addition. The reaction mixture was stirred at room temperature for about 3 days until the reaction was complete. After completion of the reaction, the homogeneous reaction mixture was concentrated under vacuum. Water (6 mL) was added to the concentrated residue and sodium bicarbonate (0.36 g, 4.3 mmol) was added all at once and stirred for 30 minutes at room temperature. The mixture was extracted several times with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under vacuum to afford methyl 4-amino-3,5-dichlorobenzoate 0.79 g (quantitative yield) as a brown solid product. Mass spectrum (MS): m/z 220 (MH+). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 500 MHz, DMSO-d6): δ 3.780 (s, 3H), 6.407 (br s, 2H), 7.731 (s, 2H).
References
[1] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 116
[2] Patent: WO2015/167795, 2015, A1. Location in patent: Page/Page column 29
METHYL 4-AMINO-3,5-DICHLOROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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