Methyl 4-amino-3-hydroxybenzoate

Product Name: Methyl 4-amino-3-hydroxybenzoate
CAS No.: 63435-16-5
Chemical Name: Methyl 4-amino-3-hydroxybenzoate
Synonyms: V R;METHYL 4-AMINO-3-HYDROXYBENZOATE;METHYL-3-HYDROXY-4-AMINOBENZOATE;4-AMINO-3-HYDROXYBENZOIC ACID ETHYL ESTER;3-HYDROXY-4-AMINOBENZOIC ACID ETHYL ESTER;4-Amino-3-hydroxybenzoic acid methyl ester;METHYL 4-AMINO-3-HYDROXYBENZENECARBOXYLATE;3-Hydroxy-4-aminobenzoic acid methyl ester;63435-16-5 Methyl 4-amino-3-hydroxybenzoate;3-HYDROXY-4-AMINOBENZOIC ACID ETHYL ESTER 97%
CBNumber: CB6217815
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 63435-16-5.mol

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Methyl 4-amino-3-hydroxybenzoate Property

Melting point:: 120-122°C
Boiling point:: 364.5±27.0 °C(Predicted)
Density: 1.305±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 8.94±0.10(Predicted)
color: Brown
BRN: 608716
InChI: InChI=1S/C8H9NO3/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4,10H,9H2,1H3
InChIKey: OCZXDVNSNDITBS-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(N)C(O)=C1
CAS DataBase Reference: 63435-16-5(CAS DataBase Reference)
NIST Chemistry Reference: Methyl 4-amino-3-hydroxybenzoate(63435-16-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS014285
Product name: methyl 4-amino-3-hydroxybenzoate
Purity: AldrichCPR
Packaging: 250mg
Price: $70.9
Updated: 2024/03/01

TCI Chemical

Product number: A3639
Product name: Methyl 4-Amino-3-hydroxybenzoate
Purity: min. 98.0 %
Packaging: 5G
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: A3639
Product name: Methyl 4-Amino-3-hydroxybenzoate
Purity: min. 98.0 %
Packaging: 25G
Price: $294
Updated: 2025/07/31

TRC

Product number: M328583
Product name: methyl 4-amino-3-hydroxybenzoate
Packaging: 1g
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4658-1-Z1
Product name: Methyl 4-amino-3-hydroxybenzoate
Purity: 98%
Packaging: 5G
Price: $53
Updated: 2021/12/16

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Methyl 4-amino-3-hydroxybenzoate Chemical Properties,Usage,Production

Uses

Methyl 4-amino-3-hydroxybenzoate is used as an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Synthesis

67-56-1

2374-03-0

63435-16-5

1. 4-Amino-3-hydroxybenzoic acid (5.0 g, 32.6 mmol) was slowly added dropwise to a mixture of 1.25 M HCl solution (100 mL) and methanol (100 mL) at 0 °C. 2. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature with continuous stirring overnight. 3. The reaction process was monitored by HPLC and it was found that there was still raw material left, so the mixture was continued to be stirred at room temperature for 48 hours. 4. After completion of the reaction, the solvent was removed by distillation under reduced pressure. 5. 5. The residue was treated with saturated aqueous sodium bicarbonate solution, followed by extraction of the aqueous phase with ethyl acetate (2×). 6. The organic extracts were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to dryness to afford the title compound methyl 4-amino-3-hydroxybenzoate (5.37 g, 97% yield) as a crystalline solid. 7. The molecular weight of the product was confirmed to be 168 (M+1)+ by low resolution mass spectrometry (LRMS) analysis.

References

[1] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 70
[2] Patent: WO2013/68554, 2013, A1. Location in patent: Page/Page column 80
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
[4] Patent: EP1382607, 2004, A2. Location in patent: Page 43
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 15, p. 3782 - 3786

Methyl 4-amino-3-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-amino-3-hydroxybenzoate Suppliers

China 138 Germany 2 India 6 Slovakia 1 Switzerland 1 United Kingdom 11 United States 23 Global 182

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View Lastest Price from Methyl 4-amino-3-hydroxybenzoate manufacturers

Honest Joy Holdings Limited

Product: Methyl4-amino-3-hydroxybenzoate 63435-16-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.3%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: Methyl 4-amino-3-hydroxybenzoate 63435-16-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

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V R

63435-16-5 Methyl 4-amino-3-hydroxybenzoate

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63435-16-5

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