4-Amino-3-hydroxybenzoic acid
- Product Name
- 4-Amino-3-hydroxybenzoic acid
- CAS No.
- 2374-03-0
- Chemical Name
- 4-Amino-3-hydroxybenzoic acid
- Synonyms
- 3-Hydroxy PABA;3-hydroxy-4-AMino acid;Oxybuprocaine Impurity 3;Oxybuprocaine EP Impurity C;3-HYDROXY-4-AMINOBENZOIC ACID;4-AMINO-3-HYDROXYBENZOIC ACID;3-hydroxy-4-aminobenzoic Acids;BENZOIC ACID, 4-AMINO-3-HYDROXY-;4-Amino-3-hydroxybenzoic Acid >4-Amino-3-hydroxybenzoic acid,98%
- CBNumber
- CB1733439
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 2374-03-0.mol
4-Amino-3-hydroxybenzoic acid Property
- Melting point:
- 211-215 °C (lit.)
- Boiling point:
- 385.7±37.0 °C(Predicted)
- Density
- 1.028
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 4.74±0.10(Predicted)
- color
- Yellow-brown to brown
- Water Solubility
- Soluble in chloroform, and aqeous ethanol, water (Partly miscible)
- BRN
- 509859
- Major Application
- peptide synthesis
- InChI
- InChI=1S/C7H7NO3/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,9H,8H2,(H,10,11)
- InChIKey
- NFPYJDZQOKCYIE-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(N)C(O)=C1
- CAS DataBase Reference
- 2374-03-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29225090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 339598
- Product name
- 4-Amino-3-hydroxybenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $78.3
- Updated
- 2026/03/19
- Product number
- 339598
- Product name
- 4-Amino-3-hydroxybenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $166
- Updated
- 2026/03/19
- Product number
- A1194
- Product name
- 4-Amino-3-hydroxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2026/03/19
- Product number
- A1194
- Product name
- 4-Amino-3-hydroxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $125
- Updated
- 2026/03/19
- Product number
- A611215
- Product name
- 4-Amino-3-hydroxybenzoic acid
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
4-Amino-3-hydroxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
yellow-brown to brown crystalline powder
Uses
4-Amino-3-hydroxybenzoic Acid is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
Uses
4-Amino-3-hydroxybenzoic acid is used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
Step 1: Preparation of 3-hydroxy-4-nitrobenzoic acid (Compound 4A)
3-Hydroxybenzoic acid (220 mg, 1.6 mmol) was dissolved in acetonitrile, and after complete dissolution, ceric ammonium nitrate (1.26 g, 2.3 mmol) was added slowly in batches and stirred at room temperature overnight. The reaction was quenched with water at the end of the reaction, extracted with ethyl acetate, the organic terms were combined, dried, concentrated under reduced pressure and then chromatographed on a column (eluting with ethyl acetate) to obtain the solid product Compound 4A (85 mg, 27% yield).
Step 2, the preparation of 4-amino-3-hydroxybenzoic acid (compound 4B)
Compound 4A (85 mg, 0.8 mmol) was dissolved in methanol, Pd/C catalyst was added and then reacted at room temperature under the protection of hydrogen overnight, at the end of the reaction, the insoluble solid was filtered to remove the solid, and the organic layer was concentrated under reduced pressure to obtain the solid was not purified and used directly for the next step of the reaction.
4-Amino-3-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-3-hydroxybenzoic acid manufacturers
- Product
- 4-amino-3-Hydroxy benzoic acid 2374-03-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
- Product
- 4-Amino-3-hydroxybenzoic acid 2374-03-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-07
- Product
- 4-Amino-3-hydroxybenzoic acid 2374-03-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-09