2-Pyridinecarboxylicacid,5-amino-,methylester(9CI)

Product Name: 2-Pyridinecarboxylicacid,5-amino-,methylester(9CI)
CAS No.: 67515-76-8
Chemical Name: 2-Pyridinecarboxylicacid,5-amino-,methylester(9CI)
Synonyms: METHYL 5-AMINOPICOLINATE;Methyl 5-amino-pyridine-2...;5-Amino-2-(carbomethoxy)pyridine;Methyl 5-amino-2-pyridinecarboxylate;Methyl 5-amino-pyridine-2-carboxylate;5-Aminopyridin-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-aMino-, Methyl ester;2-Pyridinecarboxylicacid,5-amino-,methylester(9CI);2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) ISO 9001：2015 REACH
CBNumber: CB41281325
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 67515-76-8.mol

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2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) Property

Boiling point:: 333.7±22.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.63±0.10(Predicted)
Appearance: White to light brown Solid
InChI: InChI=1S/C7H8N2O2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,8H2,1H3
InChIKey: LJYSUEZSIXOJFK-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(N)C=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332873
Product name: Methyl5-Aminopyridine-2-carboxylate
Packaging: 500mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 068601
Product name: Methyl 5-amino-pyridine-2-carboxylate
Purity: >95%
Packaging: 1g
Price: $76
Updated: 2021/12/16

AK Scientific

Product number: W7797
Product name: Methyl5-aminopyridine-2-carboxylate
Packaging: 250mg
Price: $92
Updated: 2021/12/16

Apolloscientific

Product number: OR959381
Product name: Methyl5-aminopyridine-2-carboxylate
Purity: 96%
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-D2
Product name: Methyl 5-aminopyridine-2-carboxylate
Packaging: 1g
Price: $125
Updated: 2021/12/16

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2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) Chemical Properties,Usage,Production

Uses

Methyl 5-Aminopyridine-2-Carboxylate is used in preparation of N-Hydroxypyridine-2-carboxamide, N-Hydroxypyridazine-3-carboxamide, and N-Hydroxypyrimidine-2-carboxamide derivatives as Dihydroceramide desaturase-1 inhibitors.

Synthesis

67-56-1

24242-20-4

67515-76-8

Step 1. Synthesis of methyl 5-aminopyridinecarboxylate. Thionyl chloride (178.6 ml, 2.47 mol) was slowly added to a stirred solution of 5-amino-2-pyridine carboxylic acid (170 g, 1.23 mol) in methanol (1700 ml) at 0°C. The reaction mixture was heated to reflux for 72 hours. After completion of the reaction, the mixture was cooled to 0°C and thionyl chloride (40 ml, 0.55 mol) was added again and refluxing was continued for 24 hours. At the end of the reaction, the excess thionyl chloride was removed by distillation under reduced pressure. The crude product was neutralized with aqueous sodium bicarbonate, the solid was collected by filtration and the filter cake was dried at 40-50 °C overnight to give methyl 5-aminopyridinecarboxylate (350 g). The filtrate was extracted with dichloromethane (3 x 2L), the organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated to dryness to give the crude product (200 g). All solid products were combined to give the final methyl 5-aminopyridinecarboxylate (550 g, theoretical yield 680 g, 73% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ8.12 (d, J=2.5 Hz, 1H), 7.93 (d, J=8.5 Hz, 1H), 6.97 (dd, J=2.8,8.5 Hz, 1H), 4.24 (br s, 2H), 3.93 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 413 - 417
[2] Patent: US2015/158864, 2015, A1. Location in patent: Paragraph 0292
[3] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 42 - 51
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7232 - 7246
[5] Patent: WO2016/33445, 2016, A1. Location in patent: Paragraph 0345

2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) Preparation Products And Raw materials

Raw materials

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2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) Suppliers

China 120 Europe 1 India 3 United States 12 Global 136

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View Lastest Price from 2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) 67515-76-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Methyl 5-aminopicolinate 67515-76-8
Price: US $1.60/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: methyl 5-aminopyridine-2-carboxylate 67515-76-8
Price: US $1.60/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-11-26

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2-Pyridinecarboxylicacid,5-amino-,methylester(9CI)

Methyl 5-amino-pyridine-2-carboxylate

Methyl 5-amino-pyridine-2...

METHYL 5-AMINOPICOLINATE

2-Pyridinecarboxylic acid, 5-aMino-, Methyl ester

Methyl 5-amino-2-pyridinecarboxylate

5-Amino-2-(carbomethoxy)pyridine

2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) ISO 9001：2015 REACH

5-Aminopyridin-2-carboxylic acid methyl ester

67515-76-8

Heterocycle-Pyridine series

GLYCINESCAFFOLD

CARBOXYLICESTER