ChemicalBook > CAS DataBase List > 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

Product Name
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
CAS No.
27387-31-1
Chemical Name
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Synonyms
N-Methylcarbazolone;ONDANSETRON EP IMP C;Ondansetron Impurity C;Ondansetron EP Impurity C;1,2,3,9-Tetrahydro-9-Methyl-4H;Ondansetron Related CoMpound C;Ondansetron impurity C (PhEur);1,2,3,4-tetrahydro-4-oxocarbazolt;1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE;Ondansetron USP Related Compound C
CBNumber
CB2441827
Molecular Formula
C13H13NO
Formula Weight
199.25
MOL File
27387-31-1.mol
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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Property

Melting point:
199.0 to 203.0 °C
Boiling point:
383.5±11.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
solid
color 
White to Light yellow
BRN 
153862
InChI
InChI=1S/C13H13NO/c1-14-10-6-3-2-5-9(10)13-11(14)7-4-8-12(13)15/h2-3,5-6H,4,7-8H2,1H3
InChIKey
HHJUJCWZKJMCLC-UHFFFAOYSA-N
SMILES
N1(C)C2=C(C=CC=C2)C2=C1CCCC2=O
CAS DataBase Reference
27387-31-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-52/53-25
Safety Statements 
22-24/25-61-45
RIDADR 
UN 2811 6.1 / PGIII
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2224
Product name
Ondansetron Related Compound C
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100mg
Price
$389.5
Updated
2025/07/31
Sigma-Aldrich
Product number
1478618
Product name
Ondansetron Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
30mg
Price
$1360
Updated
2025/07/31
TCI Chemical
Product number
T2942
Product name
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Purity
>98.0%(GC)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
T2942
Product name
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Purity
>98.0%(GC)
Packaging
25g
Price
$142
Updated
2025/07/31
TRC
Product number
T293920
Product name
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one
Packaging
1g
Price
$305
Updated
2021/12/16
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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Chemical Properties,Usage,Production

Chemical Properties

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is Off-White Solid

Uses

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is an impurity of Ondansetron (O655000).

Synthesis

15128-52-6

4637-24-5

27387-31-1

The reaction was carried out in N,N-dimethylformamide (5.0 mL) at reflux for 1.0 h with 2,3-dihydro-1H-carbazol-4(9H)-one (1.0 mmol) and N,N-dimethylformamide dimethyl acetal (10 mmol). After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (2 x 25 mL). The organic layer was separated and washed with saturated brine solution and subsequently dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting solid was recrystallized from ethanol to give white acicular crystals in 71% yield, melting point 188-190 °C. IR (cm-1 ): 1695 (C=O). 1H NMR (400 MHz, CDCl3) δ: 2.24-2.27 (t, 2H, CH2, J = 6.28 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz). CH2, J = 6.0 Hz), 2.91-2.94 (t, 2H, CH2, J = 6.21 Hz), 3.70 (s, 3H, NCH3), 7.27-7.30 (m, 3H, Ph), 8.24-8.26 (m, 1H, Ph). Calculated elemental analysis (C13H13NO): C, 78.36; H, 6.58; N, 7.03%. Measured values: C, 78.29; H, 6.49; N, 6.92%.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Preparation Products And Raw materials

Raw materials

Acrylic acid Phenylhydrazine

Preparation Products

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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Suppliers

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View Lastest Price from 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price
US $0.00-0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
200tons
Release date
2025-04-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-17
Henan Aochuang Chemical Co.,Ltd.
Product
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2025-04-01

27387-31-1, 1,2,3,4-Tetrahydro-9-methylcarbazol-4-oneRelated Search:

Methylparaben Tetramethylammonium hydroxide pentahydrate Paraquat dichloride Mesotrione Acetonitrile Methyl acrylate Basic Violet 1 Carbazole 4-Methyl-2-pentanone 1,1,3,3-Tetramethyldisiloxane Methyl tetrahydrophthalic anhydride 6-Methyl-5-hepten-2-one Kresoxim-methyl Methanol N-Methyl-2-pyrrolidone Methyl Ondansetron EP Impurity G 3-[(Dimethylamino)methyl]-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

  • 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE
  • 9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE
  • 9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE
  • 9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE
  • 9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE
  • 9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE
  • Ondansetron EP Impurity C (USP RC C)
  • 1,2,3,4a,9,9a‐Hexahydro‐9‐ methyl‐4H‐carbazol‐4‐one
  • 9-Methyl-1,2,3,4-tetrahydrocarbazol-4-one
  • Ondansetron Impurity C
  • Ondansetron Hydrochloride Dihydrate EP Impurity C (USP RC C)
  • 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE
  • 1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE
  • 1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE
  • 1,2,3,4-TETRAHYDRO-9METHYL-4H-CARBAZOLE-4-ONE
  • 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
  • 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99%
  • N-Methylcarbazolone
  • 1,2,3,4-tetrahydro-4-oxocarbazolt
  • 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON
  • 1,2,3,9-Tetrahydro-9-Methyl-4H
  • 1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE
  • 1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one
  • N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE
  • 9-Methyl-2,3-dihydro-1H-carbazol-4-one
  • Ondansetron HCl EP IMpurity-C (USP RC C)
  • Ondansetron Related CoMpound C
  • Ondansetron impurity C (PhEur)
  • Ondansetron Related Compound C (USP)
  • 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one
  • Ondansetron EP Impurity C
  • Ondansetron Impurity 3（Ondansetron EP Impurity C）
  • Ondansetron EP Impurity C (Ondansetron USP Related Compound C)
  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-
  • 1,2,3,4-Tetrahydro-9-methyl-4-oxocarbazole
  • 1,2,3,9-Tetrahydro-9-methylcarbazol-4-one
  • 4-Tetrahydro-9-methylcarbazol-4-one
  • Ondansetron EP Impurity C/ Ondansetron Related Compound C
  • 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)Q: What is 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the CAS Number of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the storage condition of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What are the applications of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)
  • Ondansetron Related Compound C (1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one) (1478618)
  • Ondansetron USP Related Compound C
  • Ondansetron Hydrochloride Dihydrate EP Impurity C
  • 1,2,3,9-TETRA HYDRO-9-METHYL-4(H)-CARBAZOL-4-ONE/MCZ
  • Ondansetron Related Compound C (30 mg) (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one)
  • ONDANSETRON EP IMP C
  • 2,3, - dihydro -9-methyl -1H-carbazol – 4(9H) - one
  • Ondansetron EP Impurity C 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one
  • 27387-31-1
  • 27397-31-1
  • C13H15NO
  • Aromatics
  • Heterocycles
  • Impurities
  • Intermediates