(R)-2-Methylpyrrolidine hydrochloride

Product Name: (R)-2-Methylpyrrolidine hydrochloride
CAS No.: 135324-85-5
Chemical Name: (R)-2-Methylpyrrolidine hydrochloride
Synonyms: (R)-2-METHYL-PYRROLIDINE, HCL;(R)-2-METHYLPYRROLIDINE.HCL 98.0%;(R)-2-METHYLPYRROLIDINE HYDROCHLORIDE;(R)-2-Methylpyrrolidinemonohydrochloride;(2R)-2-methyl-Pyrrolidine hydrochloride (1:1);(R)-2-Methylpyrrolidine hydrochloride - [M90991];Pyrrolidine, 2-methyl-, hydrochloride (1:1), (2R)-
CBNumber: CB2446837
Molecular Formula: C5H12ClN
Formula Weight: 121.61
MOL File: 135324-85-5.mol

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(R)-2-Methylpyrrolidine hydrochloride Property

Melting point:: 73.0 to 77.0 °C
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystaline
color: White to Almost white
optical activity: Consistent with structure
InChI: InChI=1/C5H11N.ClH/c1-5-3-2-4-6-5;/h5-6H,2-4H2,1H3;1H/t5-;/s3
InChIKey: JNEIFWYJFOEKIM-USHJBNIQNA-N
SMILES: C[C@H]1NCCC1.Cl |&1:1,r|
CAS DataBase Reference: 135324-85-5(CAS DataBase Reference)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2747
Product name: (R)-2-Methylpyrrolidine Hydrochloride
Purity: >97.0%(N)(T)
Packaging: 200mg
Price: $57
Updated: 2022/04/27

TCI Chemical

Product number: M2747
Product name: (R)-2-Methylpyrrolidine Hydrochloride
Purity: >97.0%(N)(T)
Packaging: 1g
Price: $163
Updated: 2021/12/16

TRC

Product number: M339165
Product name: (R)-2-Methylpyrrolidine Hydrochloride
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Activate Scientific

Product number: AS44074-B
Product name: (R)-2-Methylpyrrolidine hydrochloride
Purity: 95+% ee
Packaging: 1g
Price: $65
Updated: 2021/12/16

Chem-Impex

Product number: 41624
Product name: (R)-2-Methylpyrrolidinehydrochloride,97%(Assaybytitration)
Purity: 97%(Assaybytitration)
Packaging: 200MG
Price: $76.16
Updated: 2021/12/16

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(R)-2-Methylpyrrolidine hydrochloride Chemical Properties,Usage,Production

Synthesis

157007-54-0

41720-98-3

Step B: (i) Synthesis of (R)-2-methylpyrrolidine hydrochloride; (i) (R)-tert-butyl 2-methylpyrrolidine-1-carboxylate (22.7 g, 123 mmol) was dissolved in 4 M hydrogen chloride in dioxane solution (100 mL) and the reaction was stirred for 30 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio 2:1 ethyl acetate/hexane) to confirm complete consumption of the raw material. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in a solvent mixture of acetonitrile and toluene and the solvent was again removed by distillation under reduced pressure. The resulting white solid was dried overnight under reduced pressure to give (R)-2-methylpyrrolidine hydrochloride (14.6 g) in 98% yield. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δ 1.55 (d, J = 6.57 Hz, 3H), 1.66-1.77 (m, 1H), 1.95-2.04 (m, 1H), 2.05-2.23 (m, 2H), 3.25-3.36 (m, 1H), 3.37-3.48 (m, 1H), and 3.62-3.74 (m, 1H), 9.38 (s, 1H), 9.86 (s, 1H).

References

[1] Patent: WO2008/5338, 2008, A1. Location in patent: Page/Page column 80
[2] Tetrahedron, 2006, vol. 62, # 18, p. 4584 - 4589
[3] Patent: US2004/260100, 2004, A1. Location in patent: Page 8
[4] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 44
[5] Organic and Biomolecular Chemistry, 2010, vol. 8, # 20, p. 4533 - 4535

(R)-2-Methylpyrrolidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-2-Methylpyrrolidine hydrochloride Suppliers

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View Lastest Price from (R)-2-Methylpyrrolidine hydrochloride manufacturers

Career Henan Chemical Co

Product: (R)-2-Methylpyrrolidine hydrochloride 135324-85-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

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135324-85-5

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