Methyl L-prolinate hydrochloride
- Product Name
- Methyl L-prolinate hydrochloride
- CAS No.
- 2133-40-6
- Chemical Name
- Methyl L-prolinate hydrochloride
- Synonyms
- L-PROLINE METHYL ESTER HYDROCHLORIDE;PROLINE METHYL ESTER HYDROCHLORIDE;L-Proline Methyl Ester Monohydrochloride;L-Proline methyleester hydrochloride;Methyl L-prolinate hydrochloride USP/EP/BP;L-Proline methyl ester hydrochloride≥ 99% (HPLC);ine methyL;H-PRO-OME HCL;L-Pro-Ome.HCl;H-Pro-OMel.HCl
- CBNumber
- CB3116045
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 2133-40-6.mol
Methyl L-prolinate hydrochloride Property
- Melting point:
- 69-71 °C(lit.)
- alpha
- -33 º (c=1, H2O)
- Boiling point:
- 55 °C / 11mmHg
- Density
- 1.1426 (rough estimate)
- refractive index
- -31.5 ° (C=1, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform, Methanol (Slightly), Water (slightly)
- form
- Crystalline Powder, Crystals, and/or Chunks
- color
- White
- optical activity
- [α]20/D 31°, c = 0.5 in H2O
- Sensitive
- Hygroscopic
- BRN
- 3596045
- Stability:
- Hygroscopic
- InChIKey
- HQEIPVHJHZTMDP-JEDNCBNOSA-N
- CAS DataBase Reference
- 2133-40-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 287067
- Product name
- L-Proline methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 1g
- Price
- $26.25
- Updated
- 2025/07/31
- Product number
- 287067
- Product name
- L-Proline methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- P0342
- Product name
- L-Proline Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- P0342
- Product name
- L-Proline Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $224
- Updated
- 2025/07/31
- Product number
- 287067
- Product name
- L-Proline methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $118.29
- Updated
- 2025/07/31
Methyl L-prolinate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Proline Methyl Ester Hydrochloride (cas# 2133-40-6) is a compound useful in organic synthesis.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
147-85-3
2133-40-6
The general procedure for the synthesis of L-proline methyl ester hydrochloride from methanol and L-proline was as follows: first, methyl (S)-pyrrolidine-2-carboxylate was prepared by reacting (S)-proline (10.2 g, 88.6 mmol) with SOCl? (11.6 g, 7.10 mL, 97.5 mmol) in refluxed methanol (60 mL) for 29 hours. Upon completion of the reaction, excess solvent and SOCl? were removed by distillation under reduced pressure to afford the proline ester as a gray oil (15.9 g, quantitative yield). Subsequently, 2-fluoro-1-nitrobenzene (6.92 g, 5.18 mL, 49.0 mmol) was reacted with methyl (S)-pyrrolidine-2-carboxylate (7.55 g, 45.6 mmol) prepared as described above according to the literature method to afford bright yellow crystals of L-prolinylmethyl ester hydrochloride (12.0 g, quantitative yield), which was used without further purification for subsequent The product can be used for subsequent experiments without further purification.
References
[1] Heterocycles, 1986, vol. 24, # 4, p. 1045 - 1060
[2] Bulletin des Societes Chimiques Belges, 1994, vol. 103, # 5-6, p. 201 - 206
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3767 - 3775
[4] European Journal of Organic Chemistry, 2002, # 19, p. 3304 - 3314
[5] Tetrahedron, 2008, vol. 64, # 42, p. 9992 - 9998
Methyl L-prolinate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl L-prolinate hydrochloride manufacturers
- Product
- Methyl L-prolinate hydrochloride 2133-40-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 98.5%min
- Supply Ability
- 100kgs
- Release date
- 2021-08-23
- Product
- L-Pro-Ome.HCl 2133-40-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-24
- Product
- Methyl L-prolinate hydrochloride 2133-40-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30