ChemicalBook > CAS DataBase List > Methyl L-prolinate hydrochloride

Methyl L-prolinate hydrochloride

Product Name: Methyl L-prolinate hydrochloride
CAS No.: 2133-40-6
Chemical Name: Methyl L-prolinate hydrochloride
Synonyms: L-PROLINE METHYL ESTER HYDROCHLORIDE;PROLINE METHYL ESTER HYDROCHLORIDE;L-Proline Methyl Ester Monohydrochloride;L-Proline methyleester hydrochloride;Methyl L-prolinate hydrochloride USP/EP/BP;L-Proline methyl ester hydrochloride≥ 99% (HPLC);ine methyL;H-PRO-OME HCL;L-Pro-Ome.HCl;H-Pro-OMel.HCl
CBNumber: CB3116045
Molecular Formula: C6H12ClNO2
Formula Weight: 165.62
MOL File: 2133-40-6.mol

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Methyl L-prolinate hydrochloride Property

Melting point:: 69-71 °C(lit.)
alpha: -33 º (c=1, H2O)
Boiling point:: 55 °C / 11mmHg
Density: 1.1426 (rough estimate)
refractive index: -31.5 ° (C=1, H2O)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Methanol (Slightly), Water (slightly)
form: Crystalline Powder, Crystals, and/or Chunks
color: White
optical activity: [α]20/D 31°, c = 0.5 in H2O
Sensitive: Hygroscopic
BRN: 3596045
Stability:: Hygroscopic
InChIKey: HQEIPVHJHZTMDP-JEDNCBNOSA-N
CAS DataBase Reference: 2133-40-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-37/39
WGK Germany: 3
F: 3-8-10-21
Hazard Note: Harmful
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 287067
Product name: L-Proline methyl ester hydrochloride
Purity: 98%
Packaging: 1g
Price: $26.25
Updated: 2025/07/31

Sigma-Aldrich

Product number: 287067
Product name: L-Proline methyl ester hydrochloride
Purity: 98%
Packaging: 5g
Price: $104
Updated: 2025/07/31

TCI Chemical

Product number: P0342
Product name: L-Proline Methyl Ester Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: P0342
Product name: L-Proline Methyl Ester Hydrochloride
Purity: >98.0%(N)
Packaging: 25g
Price: $224
Updated: 2025/07/31

Sigma-Aldrich

Product number: 287067
Product name: L-Proline methyl ester hydrochloride
Purity: 98%
Packaging: 25g
Price: $118.29
Updated: 2025/07/31

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Methyl L-prolinate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Proline Methyl Ester Hydrochloride (cas# 2133-40-6) is a compound useful in organic synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

147-85-3

2133-40-6

The general procedure for the synthesis of L-proline methyl ester hydrochloride from methanol and L-proline was as follows: first, methyl (S)-pyrrolidine-2-carboxylate was prepared by reacting (S)-proline (10.2 g, 88.6 mmol) with SOCl? (11.6 g, 7.10 mL, 97.5 mmol) in refluxed methanol (60 mL) for 29 hours. Upon completion of the reaction, excess solvent and SOCl? were removed by distillation under reduced pressure to afford the proline ester as a gray oil (15.9 g, quantitative yield). Subsequently, 2-fluoro-1-nitrobenzene (6.92 g, 5.18 mL, 49.0 mmol) was reacted with methyl (S)-pyrrolidine-2-carboxylate (7.55 g, 45.6 mmol) prepared as described above according to the literature method to afford bright yellow crystals of L-prolinylmethyl ester hydrochloride (12.0 g, quantitative yield), which was used without further purification for subsequent The product can be used for subsequent experiments without further purification.

References

[1] Heterocycles, 1986, vol. 24, # 4, p. 1045 - 1060
[2] Bulletin des Societes Chimiques Belges, 1994, vol. 103, # 5-6, p. 201 - 206
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3767 - 3775
[4] European Journal of Organic Chemistry, 2002, # 19, p. 3304 - 3314
[5] Tetrahedron, 2008, vol. 64, # 42, p. 9992 - 9998

Methyl L-prolinate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl L-prolinate hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl L-prolinate hydrochloride 2133-40-6
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98.5%min
Supply Ability: 100kgs
Release date: 2021-08-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Pro-Ome.HCl 2133-40-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-24

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl L-prolinate hydrochloride 2133-40-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

2133-40-6, Methyl L-prolinate hydrochlorideRelated Search:

tert-Butyl L-prolinate hydrochloride Kresoxim-methyl L-PROLINE-(4-3H(N)) Methyl acrylate D-Proline Bensulfuron methyl Methylparaben cis-4-Hydroxy-L-proline Topotecan hydrochloride L-Alanine methyl ester hydrochloride H-PRO-OTBU Thiophanate-methyl Methyl H-PRO-HYP-OH tert-butyl 5-oxo-L-prolinate H-SER-GLY-OH Ethyl L-serinate hydrochloride 2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI)

(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride

L-Proline methyl ester hydrochloride≥ 99% (HPLC)

Methyl L-prolite hydrochloride

L-Proline methyleester hydrochloride

H-L-PRO-OME HCL

H-PRO-OME HCL

L-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER HCL

L-PROLINE METHYL ESTER HYDROCHLORIDE

L-PROLINE METHYL ESTER HYDROCHLORIDE SALT

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PAPAIN SUSPENSION IN 0.05 M SODIUM*ACETA TE

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L-Proline methyl ester hydrochloride 98%

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ine methyL

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METHYL 2-PYRROLIDINE CARBOXYLATE HYDROCHLORIDE

L-PRALINE METHYLESTER HYDROCHLORIDE

PROLINE METHYL ESTER HYDROCHLORIDE

Proline, Methyl ester, HCl

L-Proline methyl ester hydrochloride, 98+%

L-Sroline methyl ester hydrochloride, 98%

(2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloric acid

(2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloride

L-Proline methyl·hydrochloric acid

L-Pro-OMe·Hydrochloride

Proline methyl·hydrochloride

L-Prolin Methyl Ester Hydrochloride

methyl－prolinatehydrochloride

(2S)-Methyl pyrrolidine-2-carboxylate hydrochloride 98%

L-Proline methyl est

L-Proline methyl ester hydrochloride, Methyl L-prolinate hydrochloride

Methyl (2S)-pyrrolidine-2-carboxylate hydrochloride

L-Proline Methyl ester hydrochloride, 98% 1GR

L-Proline Methyl Ester Monohydrochloride

Methyl Proline Hydrochloride

2-pyrrolidinecarboxylic acid methyl ester hydrochloride

(2S)-Methyl pyrrolidine-2-carboxylate hydrochloride

L-ProlineMethylEsterHydrochloride&gt

2133-40-6 (L-PROLINE METHYL ESTER HYDROCHLORIDE)

Methyl L-prolinate hydrochloride USP/EP/BP

L-Proline, methyl ester, hydrochloride (1:1)

H-Pro-OMel.HCl

<sc>L</sc>-Proline methyl ester hydrochloride

L-proline methyl ester hydrochloride, 98.5%min

methyl (2S)-pyrrolidine-2-carboxylate hydrochloride - [M22329]

L-Pro-Ome.HCl

2133-40-6

C6H11NO2ClH

Peptide Synthesis

Specialty Synthesis

Amino Acid Derivatives

Proline [Pro, P]

Amino Acids and Derivatives