2-(2-Methylpropyl)pyridine

Product Name: 2-(2-Methylpropyl)pyridine
CAS No.: 6304-24-1
Chemical Name: 2-(2-Methylpropyl)pyridine
Synonyms: FEMA 3370;FEMA NUMBER 3370;2-ISOBUTYLPYRIDINE;2-(2-METHYLPROPYL) PYRIDINE;Pyridine, 2-(2-methylpropyl)-
CBNumber: CB2454285
Molecular Formula: C9H13N
Formula Weight: 135.21
MOL File: 6304-24-1.mol

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2-(2-Methylpropyl)pyridine Property

Boiling point:: 180-185 °C
Density: 0.899
FEMA: 3370 | 2-(2-METHYLPROPYL)PYRIDINE
storage temp.: Inert atmosphere,Room Temperature
pka: 5.83±0.19(Predicted)
Odor: at 0.10 % in dipropylene glycol. strong aromatic bell pepper
Odor Type: aromatic
JECFA Number: 1311
LogP: 2.60
CAS DataBase Reference: 6304-24-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: I786523
Product name: 2-Isobutylpyridine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: FFG0002826
Product name: 2-ISOBUTYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.9
Updated: 2021/12/16

Crysdot

Product number: CD11084107
Product name: 2-Isobutylpyridine
Purity: 95+%
Packaging: 25g
Price: $398
Updated: 2021/12/16

AHH

Product number: MT-16007
Product name: 2-Isobutylpyridine
Purity: 99%
Packaging: 100g
Price: $455
Updated: 2021/12/16

Chemenu

Product number: CM173984
Product name: 2-Isobutylpyridine
Purity: 95%
Packaging: 10g
Price: $210
Updated: 2021/12/16

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2-(2-Methylpropyl)pyridine Chemical Properties,Usage,Production

Description

May be prepared from 2-pycolyllithium and isopropyl bromide; from 2-methyl pyridine and isopropyl bromide in liquid ammonia in the presence of potassium metal and ferric nitrate.

Preparation

From β-picoline with NaNH2 and alkyl chloride or bromide.

Definition

ChEBI: 2-(2-Methylpropyl)pyridine is a member of pyridines.

Synthesis

100-71-0

823-96-1

622-39-9

6304-24-1

The methylation reaction was carried out by General Method 2 using 2-ethylpyridine and trimethylcyclotriboroxane as raw materials. Upon completion of the reaction, the products were purified by column chromatography to give two products: 21 (2-propylpyridine) as a colorless oil (19.1 mg, 79% yield) and 13a (2-isobutylpyridine) as a colorless oil (3.0 mg, 11% yield). The NMR data for 21 (2-propylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.8 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.14 (d, J = 8.0 Hz, 1H), 7.11-7.08 (m, 1H), 2.77 (t, J = 7.6 Hz, 2H), 1.81-1.71 (m, 2H), 0.97 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ 162.35, 149.26, 136.25, 122.83, 120.94, 40.49, 23.19, 13.94; HRMS (EI): calculated value C8H11N (M+) 121.0891, measured value 121.0893. The NMR data of 13a (2-isobutylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.4 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.12-7.08 (m, 2H), 2.65 (d, J = 7.6 Hz, 2H), 2.15-2.05 (m, 1H), 0.93 (d, J = 6.8 Hz, 6H); 13C NMR (100 MHz). 13C NMR (100 MHz, CDCl3) δ 161.89, 149.50, 136.34, 123.81, 121.19, 47.93, 29.57, 22.74; HRMS (EI): calculated value C9H13N (M+) 135.1048, measured value 135.1046. Reaction conditions: in a 40 mL reaction tube, the substrate (0.2 mmol, 1 eq.), Pd(OAc)2 (4.5 mg, 0.02 mmol, 10 mol%), methyl cycloboroxane (55.7 μL, 0.4 mmol, 2 eq.), Cu(OAc)2 (72.8 mg, 0.4 mmol, 2 eq.) and benzoquinone (43.2 mg, 0.4 mmol, 2 eq.) were mixed together. 0.4 mmol, 2 eq.) were dissolved in 1 mL of acetic acid and reacted under oxygen atmosphere. The reaction tube was sealed with a PTFE-lined cap and the reaction mixture was stirred at 100 °C for 24 hours. After completion of the reaction, it was neutralized to pH=8-9 with 4N NaOH aqueous solution and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a diatomaceous earth pad and the diatomaceous earth was washed with 20 mL of dichloromethane. The filtrate was washed twice with saturated brine and the organic layer was dried with Na2SO4 and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane:ether=10:1) to give the methylated product.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12634 - 12635
[2] Patent: WO2008/24953, 2008, A2. Location in patent: Page/Page column 6; 62; 67-68
[3] Patent: WO2008/24953, 2008, A2. Location in patent: Page/Page column 6; 62; 67-68

2-(2-Methylpropyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-Methylpropyl)pyridine Suppliers

China 34 Germany 2 India 1 United Kingdom 8 United States 17 USA 1 Global 63

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View Lastest Price from 2-(2-Methylpropyl)pyridine manufacturers

Career Henan Chemical Co

Product: 2-Isobutylpyridine 6304-24-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-03

6304-24-1, 2-(2-Methylpropyl)pyridineRelated Search:

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FEMA NUMBER 3370

FEMA 3370

2-ISOBUTYLPYRIDINE

2-(2-METHYLPROPYL) PYRIDINE

Pyridine, 2-(2-methylpropyl)-

6304-24-1

Organics