3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- Product Name
- 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- CAS No.
- 83279-38-3
- Chemical Name
- 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- Synonyms
- 3-chloro-4-trifluoromethoxybenaldehyde;3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE;Benzaldehyde, 3-chloro-4-(trifluoromethyl)-
- CBNumber
- CB2461898
- Molecular Formula
- C8H4ClF3O
- Formula Weight
- 208.57
- MOL File
- 83279-38-3.mol
3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Property
- Boiling point:
- 232.9±40.0 °C(Predicted)
- Density
- 1.42g/ml
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, colourless
- Water Solubility
- Insoluble in water.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C596798
- Product name
- 3-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C596798
- Product name
- 3-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC137980
- Product name
- 3-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC137980
- Product name
- 3-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 2815-7-07
- Product name
- 3-Chloro-4-(trifluoromethyl)benzaldehyde
- Packaging
- 5G
- Price
- $149
- Updated
- 2021/12/16
3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Chloro-4-(trifluoromethyl)benzaldehyde is used in synthesis of organic compunds in γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.
Synthesis
1092460-79-1
83279-38-3
The general procedure for the synthesis of 3-chloro-4-trifluoromethylbenzonitrile from 3-chloro-4-trifluoromethylbenzaldehyde was as follows: at 0 °C, using a syringe, diisobutylaluminum hydride (1.0 M toluene solution, 28 mL, 28 mmol) was added slowly and dropwise to 3-chloro-4-(trifluoromethyl)benzonitrile (3.79 g, 18.4 mmol) in tetrahydrofuran (THF, 50 mL ) solution. The reaction mixture was kept at 0 °C for 2 h, followed by warming to room temperature and continued stirring for 2 h. The reaction was carried out on a cooled surface. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with 3M aqueous hydrochloric acid solution (75 mL). The mixture was warmed to room temperature and stirred vigorously for 1.5 hours. Subsequently, the mixture was transferred to a dispensing funnel and diluted with ether (Et2O). The organic phase was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification by fast chromatography (Analogix? IntelliFlash 280? system, using 15% ethyl acetate/hexane as eluent, SF40-150g column) gave 2.84 g (74% yield) of 3-chloro-4-trifluoromethylbenzaldehyde as a colorless oil. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 10.09 (s, 1H), 8.21 (s, 1H), 8.12 (d, J = 8.1 Hz, 1H), 8.07-8.02 (m, 1H).
References
[1] Patent: US2009/124666, 2009, A1. Location in patent: Page/Page column 30-32
3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Suppliers
- Tel
- --
- Fax
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- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
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View Lastest Price from 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE manufacturers
- Product
- 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE 83279-38-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1MT/month
- Release date
- 2019-07-31