(-)-BICUCULLINE METHOBROMIDE

Product Name: (-)-BICUCULLINE METHOBROMIDE
CAS No.: 73604-30-5
Chemical Name: (-)-BICUCULLINE METHOBROMIDE
Synonyms: Bicuculineracemic;Bicuculinemethoiodide;(-）Bicucullinemethobromide;l-Bicuculline methobromide;(-)-BICUCULLINE METHOBROMIDE;(-)-BICUCULLINE 1(S),9(R) METHBROMIDE;( ) Bicuculline methobromide,()Bicuculline methobromide;(R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq;(6R)-6-[(5R)-6,6-diMethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-iuM-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one broMide;[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
CBNumber: CB2461919
Molecular Formula: C21H20NO6.Br
Formula Weight: 462.29
MOL File: 73604-30-5.mol

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(-)-BICUCULLINE METHOBROMIDE Property

storage temp.: 2-8°C
solubility: aqueous base: unstable
form: solid
color: white
Water Solubility: Soluble in water (50mM)
Sensitive: Light Sensitive

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Safety

Safety Statements: 24/25
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H330Fatal if inhaled

H400Very toxic to aquatic life

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B382513
Product name: (-)-Bicucullinemethobromide
Packaging: 50mg
Price: $125
Updated: 2021/12/16

ApexBio Technology

Product number: B6207
Product name: (-)-Bicucullinemethobromide
Packaging: 10mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-0020423
Product name: (-)-Bicucullinemethobromide
Purity: ≥99.0%
Packaging: 10mg
Price: $560
Updated: 2021/12/16

ApexBio Technology

Product number: B6207
Product name: (-)-Bicucullinemethobromide
Packaging: 50mg
Price: $660
Updated: 2021/12/16

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(-)-BICUCULLINE METHOBROMIDE Chemical Properties,Usage,Production

Uses

(-)-Bicuculline methobromide is an N-methylated derivative of the GABAA?antagonist bicuculline.

Biological Activity

Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

in vivo

(-)-Bicuculline methobromide can be used in animal modeling to create epilepsy models and is capable of crossing the blood-brain barrier^[3].

1. Induction of epilepsy^[3]

Background

(-)-Bisculline methoromide can inhibit the synthesis and release of GABA, and weaken GABA's inhibition of neuronal activity in the SN reticular region (SNr), leading to epilepsy.

Specific Mmodeling Methods

Rat: Sprague-Dawley (SD) ? male or female ? 2 weeks old
Administration: 12.5, 25, 50 or 100 ng/0.25 μL ? inject into SN or corpus striatum through bilateral catheter implantation

Note

(1) Dissolve (-)-Bicuculine methoromide in distilled water and administer at a volume of 0.25 μL.
(2) Simultaneously administer bilateral infusions at a rate of 0.25 μ L/min, and after the infusion is completed, insert the catheter in situ for an additional minute to prevent drug reflux.
(3) Due to the short-lived effect of (-) - Bicuculine methoromide in SN, rats were tested 5 minutes after completing the infusion.

Modeling Indicators

Behavioral observation: Shortened the latency period of epileptic seizures, causing stereotyped behaviors such as excessive sniffing or licking, chewing movements, head twitching, and slow or occasional circling.

Correlated Product(s): Muscimol (HY-N2313)

Opposite Product(s): /

Animal Model:	Rat L5-SNL model^[2]
Dosage:	0.6 nmol/rat
Administration:	Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:	Attenuated the antiallodynic effect of Neurotropin.

storage

Room temperature

(-)-BICUCULLINE METHOBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-BICUCULLINE METHOBROMIDE Suppliers

China 20 France 1 Germany 3 Japan 2 Switzerland 3 United Kingdom 3 United States 9 Global 41

AXXORA, LLC

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Alexis Corporation

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73604-30-5, (-)-BICUCULLINE METHOBROMIDERelated Search:

dioxifedrine Homovanillyl alcohol (-)-BICUCULLINE METHOBROMIDE 1-(4-methoxyphenyl)propan-2-ol 3-METHOXYPHENETHYL ALCOHOL Salsoline 1,3-BENZODIOXOLE-4-CARBOXYLIC ACID 3-Methoxysalicylic acid Norepinephrine SYNEPHRINE 2,3-Dihydroxybenzoic acid Leptodactyline Ethyl 3-hydroxybenzoate 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL (+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE BENZOYLCHOLINE BROMIDE 5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLINE

[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINDINIUM BROMIDE

[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM BROMIDE

(-)-BICUCULLINE 1(S),9(R) METHBROMIDE

(-)-BICUCULLINE METHOBROMIDE

Bicuculineracemic

(R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq

Bicuculinemethoiodide

[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide

(6R)-6-[(5R)-6,6-diMethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-iuM-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one broMide

l-Bicuculline methobromide

(-）Bicucullinemethobromide

( ) Bicuculline methobromide,()Bicuculline methobromide

1,3-Dioxolo[4,5-g]isoquinolinium, 5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-, bromide (1:1), (5R)-

73604-30-5

GABA

GABA/Glycine receptor