2,3-Dihydroxybenzoic acid
- Product Name
- 2,3-Dihydroxybenzoic acid
- CAS No.
- 303-38-8
- Chemical Name
- 2,3-Dihydroxybenzoic acid
- Synonyms
- Pyrocatechuic acid;2,3-dihydroxybenzoate;O-PYROCATECHUIC ACID;DOBK;2,3 DHB;NSC 27435;RARECHEM AL BE 0035;TIMTEC-BB SBB008367;2-pyrocatechuicacid;2,3-Dihydroxybenzoic
- CBNumber
- CB3481462
- Molecular Formula
- C7H6O4
- Formula Weight
- 154.12
- MOL File
- 303-38-8.mol
2,3-Dihydroxybenzoic acid Property
- Melting point:
- 204-206 °C (lit.)
- Boiling point:
- 95-96/0.5mm
- Density
- 1,542 g/cm3
- refractive index
- 1.6400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- methanol: soluble50mg/mL, clear to faintly hazy, orange
- pka
- pK1:2.98;pK2:10.14 (30°C)
- form
- Crystalline Powder
- color
- Beige to brown or pinkish-gray
- Water Solubility
- Soluble in water, methanol and dimethyl sulfoxide.
- BRN
- 2209117
- InChIKey
- GLDQAMYCGOIJDV-UHFFFAOYSA-N
- LogP
- 1.200
- CAS DataBase Reference
- 303-38-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 2,3-dihydroxy-(303-38-8)
- EPA Substance Registry System
- 2,3-Dihydroxybenzoic acid (303-38-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- DG8576490
- Hazard Note
- Irritant
- HS Code
- 29182900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 126209
- Product name
- 2,3-Dihydroxybenzoic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $62.1
- Updated
- 2025/07/31
- Product number
- C0054
- Product name
- 2,3-Dihydroxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- C0054
- Product name
- 2,3-Dihydroxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- D451650
- Product name
- 2,3-Dihydroxybenzoic acid
- Packaging
- 5g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2629-1-Z5
- Product name
- 2,3-Dihydroxybenzoic acid
- Packaging
- 10g
- Price
- $17
- Updated
- 2021/12/16
2,3-Dihydroxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Pale Brownish to Red Brownish Crystalline Powder. 2,3-Dihydroxybenzoic Acid [303-38-8], C7H6O4, Mr 154.1, mp 206℃, undergoes decomposition to catechol and carbon dioxide. The acid crystallizes from water as a dihydrate. Among other uses, it serves as an iron-complexing agent in drugs.
Uses
2,3-Dihydroxybenzoic Acid is a selected phenol as MMP (Matrix Metalloproteinase) inhibitor.
Uses
2,3-Dihydroxybenzoic acid was used to study the complexes of manganese with aliphatic and aromatic polyhydroxy ligands in basic media by electrochemical, spectrophotometric and magnetic methods. It was used in isolation of new siderophore named vulnibactin from low iron cultures of Vibrio vulnificus, a human pathogen. It was used as cocrystal former to study the influence of position isomerism on the co-crystals formation and physicochemical properties of piracetam.
Definition
ChEBI: A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.
Biochem/physiol Actions
2,3-Dihydroxybenzoic acid was found to be orally effective iron-chelating drug in hypertransfused rat model. It is monocatechol siderophore produced by Brucella abortus.
Synthesis
There are two main routes for the preparation of 2,3-dihydroxybenzoic acid (2,3-DHBA): chemical synthesis and biosynthesis. The classic chemical synthesis method is the carboxylation of catechol, similar to the Kolbe-Schmidt reaction. This method typically involves reacting catechol with an alkali metal salt (such as sodium or potassium salt) under high temperature (approximately 200°C) and high pressure (several megapascals) carbon dioxide atmosphere, resulting in the substitution of the ortho- and ortho-positions of the benzene ring with a carboxyl group (-COOH). Subsequent acidification yields the target product. Furthermore, with the development of green chemistry, biosynthesis has also become an important preparation method. For example, specific microorganisms or enzymes (such as the reverse reaction of 2,3-dihydroxybenzoic acid decarboxylase) can be used to achieve the carboxylation of catechol, or 2,3-dihydroxybenzoic acid can be prepared through the 3-hydroxylation of salicylic acid.
2,3-Dihydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dihydroxybenzoic acid manufacturers
- Product
- 2,3-Dihydroxybenzoic acid 303-38-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- 2,3-Dihydroxybenzoic acid 303-38-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 2,3-Dihydroxybenzoic acid 303-38-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10