1-NAPHTHOHYDROXAMIC ACID
- Product Name
- 1-NAPHTHOHYDROXAMIC ACID
- CAS No.
- 6953-61-3
- Chemical Name
- 1-NAPHTHOHYDROXAMIC ACID
- Synonyms
- NSC 57457;Naphthohydroxamicacid;a-Naphthohydroxamic acid;1-NAPHTHOHYDROXAMIC ACID;1-NaphthohydroxamicAcid>alpha-naphthohydroxamicacid;1-NAPHTHOHYDROXAMIC ACID 98+%;HDAC Inhibitor XIX, Compound 2;n-hydroxy-1-naphthalenecarboxamid;1-Naphthalenecarbohydroximic acid
- CBNumber
- CB2462406
- Molecular Formula
- C11H9NO2
- Formula Weight
- 187.19
- MOL File
- 6953-61-3.mol
1-NAPHTHOHYDROXAMIC ACID Property
- Melting point:
- 176-178 °C
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- pka
- 8.91±0.30(Predicted)
- form
- White solid
- color
- white to tan
Safety
- Risk Statements
- 52
- WGK Germany
- 3
- RTECS
- QJ1894500
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 382177
- Product name
- HDAC Inhibitor XIX, Compound 2
- Packaging
- 50mg
- Price
- $110
- Updated
- 2023/01/07
- Product number
- N0023
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $338
- Updated
- 2025/07/31
- Product number
- N369018
- Product name
- 1-Naphthohydroxamic Acid
- Packaging
- 5mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0108907
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0108907
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
1-NAPHTHOHYDROXAMIC ACID Chemical Properties,Usage,Production
Uses
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
Biochem/physiol Actions
1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
in vivo
Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. 1-Naphthohydroxamic acid has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed[3].
Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15?min, with a plasma peak concentration of ~30?μM[3].
| Animal Model: | NMRI Foxn1 nude mice[3] |
| Dosage: | 0 mg/kg, 50 mg/kg, 100mg/kg, 200 mg/kg, 300 mg/kg 400 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 10 days |
| Result: | Dose-limiting toxicities (DLTs) included weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. |
IC 50
HDAC8: 14 μM (IC50); HDAC1: >100 μM (IC50); HDAC6: >100 μM (IC50)
1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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