1-NAPHTHOHYDROXAMIC ACID
- Product Name
- 1-NAPHTHOHYDROXAMIC ACID
- CAS No.
- 6953-61-3
- Chemical Name
- 1-NAPHTHOHYDROXAMIC ACID
- Synonyms
- NSC 57457;Naphthohydroxamicacid;a-Naphthohydroxamic acid;1-NAPHTHOHYDROXAMIC ACID;1-NaphthohydroxamicAcid>alpha-naphthohydroxamicacid;1-NAPHTHOHYDROXAMIC ACID 98+%;HDAC Inhibitor XIX, Compound 2;n-hydroxy-1-naphthalenecarboxamid;1-Naphthalenecarbohydroximic acid
- CBNumber
- CB2462406
- Molecular Formula
- C11H9NO2
- Formula Weight
- 187.19
- MOL File
- 6953-61-3.mol
1-NAPHTHOHYDROXAMIC ACID Property
- Melting point:
- 176-178 °C
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- pka
- 8.91±0.30(Predicted)
- form
- White solid
- color
- white to tan
Safety
- Risk Statements
- 52
- WGK Germany
- 3
- RTECS
- QJ1894500
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 382177
- Product name
- HDAC Inhibitor XIX, Compound 2
- Packaging
- 50mg
- Price
- $110
- Updated
- 2023/01/07
- Product number
- N0023
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $375
- Updated
- 2024/03/01
- Product number
- N369018
- Product name
- 1-Naphthohydroxamic Acid
- Packaging
- 5mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0108907
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0108907
- Product name
- 1-Naphthohydroxamic Acid
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
1-NAPHTHOHYDROXAMIC ACID Chemical Properties,Usage,Production
Uses
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
Biochem/physiol Actions
1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
1-NAPHTHOHYDROXAMIC ACID Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75