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FTBMT

Product Name
FTBMT
CAS No.
1358575-02-6
Chemical Name
FTBMT
Synonyms
FTBMT;TP-024;FTBMT >=98% (HPLC);FTBMT, 10 mM in DMSO;inhibit,FTBMT,Inhibitor;4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
CBNumber
CB24662565
Molecular Formula
C19H16F4N4O
Formula Weight
392.35
MOL File
1358575-02-6.mol
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FTBMT Property

storage temp. 
Store at -20°C
solubility 
DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM)
form 
Solid
color 
Light yellow to orange
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6784
Product name
FTBMT
Purity
≥98%(HPLC)
Packaging
25
Price
$360
Updated
2021/12/16
TRC
Product number
F810408
Product name
FTBMT
Packaging
2.5mg
Price
$210
Updated
2021/12/16
Biosynth Carbosynth
Product number
BF161243
Product name
FTBMT NEW
Packaging
10mg
Price
$175
Updated
2021/12/16
AK Scientific
Product number
8363DM
Product name
Ftbmt
Packaging
10mg
Price
$286
Updated
2021/12/16
Biosynth Carbosynth
Product number
BF161243
Product name
FTBMT NEW
Packaging
50mg
Price
$612.5
Updated
2021/12/16
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FTBMT Chemical Properties,Usage,Production

Uses

FTBMT is a GPR52 receptor agonist with an EC50 value of 71 nM. Studies demonstrate antipsychotic-like effects of FTBMT in murine models of schizophrenia. FTBMT elicits beneficial effects on cognitive processes such as spatial working memory and long-term memory in mice.

Biological Activity

FTBMT is an orally available, selective and potent agonist of GPR52. It exhibits antipsychotic and procognitive properties without causing catalepsy in rodents. FTBMT improves recognition memory in a novel object recognition test and mitigates MK-801-induced working memory deficits in a radial arm maze test in rats.

in vivo

TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice[2].

TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats[2].

TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition[2].

Animal Model:Male Long-Evans rats (9 weeks old)[2]
Dosage:10 mg/kg
Administration:Oral, 1 hour before memory test
Result:A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801[2].
Animal Model:Male ICR mice (7 to 8 weeks old)[2]
Dosage:3–30 mg/kg
Administration:Oral, 60 minutes before s.c. administration of MK-801
Result:FTBMT increases phospho-DARPP32 levels in the NAc slices[2].

storage

Store at -20°C

FTBMT Preparation Products And Raw materials

Raw materials

Preparation Products

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FTBMT Suppliers

China 49 United States 4 Global 53
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1358575-02-6, FTBMTRelated Search:


  • FTBMT
  • Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
  • FTBMT >=98% (HPLC)
  • 4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
  • inhibit,FTBMT,Inhibitor
  • TP-024
  • 4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
  • FTBMT, 10 mM in DMSO
  • 1358575-02-6