AD57 (hydrochloride)

Product Name: AD57 (hydrochloride)
CAS No.: 2320261-72-9
Chemical Name: AD57 (hydrochloride)
Synonyms: AD57 (hydrochloride);N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride
CBNumber: CB24666215
Molecular Formula: C22H21ClF3N7O
Formula Weight: 491.8966496
MOL File: 2320261-72-9.mol

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AD57 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMF: 14 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13975
Product name: AD57 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 13975
Product name: AD57 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 13975
Product name: AD57 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

ApexBio Technology

Product number: C3080
Product name: AD57(hydrochloride)
Packaging: 10mg
Price: $543
Updated: 2021/12/16

ApexBio Technology

Product number: C3080
Product name: AD57(hydrochloride)
Packaging: 5mg
Price: $307
Updated: 2021/12/16

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AD57 (hydrochloride) Chemical Properties,Usage,Production

Description

Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.¹ In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC₅₀ = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.¹ Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.¹

References

1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486,80-84(2012).

AD57 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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AD57 (hydrochloride) Suppliers

China 20 United States 2 Global 22

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2320261-72-9, AD57 (hydrochloride)Related Search:

AD57 (hydrochloride)

N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride

2320261-72-9