AD57 (hydrochloride)
- Product Name
- AD57 (hydrochloride)
- CAS No.
- 2320261-72-9
- Chemical Name
- AD57 (hydrochloride)
- Synonyms
- AD57 (hydrochloride);N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride
- CBNumber
- CB24666215
- Molecular Formula
- C22H21ClF3N7O
- Formula Weight
- 491.8966496
- MOL File
- 2320261-72-9.mol
AD57 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 14 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 13975
- Product name
- AD57 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 13975
- Product name
- AD57 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 13975
- Product name
- AD57 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- C3080
- Product name
- AD57(hydrochloride)
- Packaging
- 10mg
- Price
- $543
- Updated
- 2021/12/16
- Product number
- C3080
- Product name
- AD57(hydrochloride)
- Packaging
- 5mg
- Price
- $307
- Updated
- 2021/12/16
AD57 (hydrochloride) Chemical Properties,Usage,Production
Description
Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.1 In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.1
References
1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-
AD57 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
AD57 (hydrochloride) Suppliers
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