ChemicalBook > CAS DataBase List > Tauro--muricholic Acid (sodium salt)

Tauro--muricholic Acid (sodium salt)

Product Name: Tauro--muricholic Acid (sodium salt)
CAS No.: 145022-92-0
Chemical Name: Tauro--muricholic Acid (sodium salt)
Synonyms: T-βMCA sodium;Tauro-β-muricholic acid sodium;Tauro-β-muricholic Acid sodium salt;Tauro-muricholic Acid (sodium salt);D4-Tauro-β-muricholic Acid Sodium Salt;Tauro-β-Muricholic Acid-[d5] Sodium Salt;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt
CBNumber: CB24667085
Molecular Formula: C26H46NNaO7S
Formula Weight: 539.7
MOL File: 145022-92-0.mol

Less

Tauro--muricholic Acid (sodium salt) Property

Melting point:: 120-125oC
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Pale Beige
Stability:: Hygroscopic

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 20289
Product name: Tauro-β-muricholic Acid (sodium salt)
Purity: ≥95%
Packaging: 500μg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 20289
Product name: Tauro-β-muricholic Acid (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 20289
Product name: Tauro-β-muricholic Acid (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $424
Updated: 2024/03/01

TRC

Product number: T009135
Product name: Tauro-β-muricholicAcidSodiumSalt
Packaging: 0.5mg
Price: $215
Updated: 2021/12/16

AK Scientific

Product number: 3131EL
Product name: Tauro-beta-muricholicacid(sodium)
Packaging: 1mg
Price: $248
Updated: 2021/12/16

Less

Tauro--muricholic Acid (sodium salt) Chemical Properties,Usage,Production

Description

Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC₅₀ = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid . TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor. TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.

Uses

Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies.

in vivo

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression^[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17^[3].

Animal Model:	APCmin/+ mice^[3]
Dosage:	400 mg/kg
Administration:	Oral gavage; twice a week; for 6 weeks
Result:	Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.

References

[1] SAMA I SAYIN. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.[J]. Cell metabolism, 2013, 17 2: 225-235. DOI: 10.1016/j.cmet.2013.01.003
[2] A. WAHLSTR?M. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota[S][J]. Journal of Lipid Research, 2017, 58 1: 412-419. DOI: 10.1194/jlr.m072819
[3] YUNPENG QI . Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 1: Pages 19-29. DOI: 10.1016/j.bbalip.2014.04.008

Tauro--muricholic Acid (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Tauro--muricholic Acid (sodium salt) Suppliers

China 37 India 1 United States 6 Global 44

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Manhag Testing Technology Co., Ltd

Tel: 020-3846 2365 19110442770
Email: 458677837@qq.com
Country: China
ProdList: 7775
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai klamar Reagent Co., LTD

Tel: 4001650900 13817534909
Email: 3003940895@qq.com
Country: China
ProdList: 10714
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9650
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

BePure (Beijing) Biotechnology Co.

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 6620
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11146
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Selection Bioscience LLC

Tel: 021-53308090 18621190837
Email: hr@selectionbio.com
Country: China
ProdList: 33
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Afflon Pharmaceutical (Sichuan) Co., Ltd.

Tel: 17336178085
Email: 1684779048@qq.com
Country: China
ProdList: 1837
Advantage: 58

ShangHai ZskBio CO., LTD

Tel: 021-58056897 15399714481
Email: info@zsklab.com
Country: China
ProdList: 7190
Advantage: 58

Suzhou Derivative Biotechnology Co., Ltd.

Tel: 13915541704
Email: 2436368162@qq.com
Country: China
ProdList: 554
Advantage: 58

Foshan Minghua Biotechnology Co., Ltd.

Tel: 18312287787
Country: CHINA
ProdList: 196
Advantage: 58

Guangzhou Leyan Technology Co., Ltd.

Tel: 13826120068
Country: CHINA
ProdList: 195
Advantage: 58

Guangzhou Lucheng Biotechnology Co., Ltd.

Tel: 16620452357
Country: CHINA
ProdList: 0
Advantage: 58

Guangzhou Songyun Biotechnology Co., Ltd.

Tel: 18026401966
Country: CHINA
ProdList: 185
Advantage: 58

Lucheng (Shenzhen) Technology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 181
Advantage: 58

Shanghai Puyu Biotechnology Co., Ltd.

Tel: 13512129615
Country: CHINA
ProdList: 129
Advantage: 58

Guangzhou Dedou Life Science Co., Ltd

Tel
Country: CHINA
ProdList: 0
Advantage: 58

Shanghai Hongmai Biotechnology Co., Ltd.

Tel: 400-920-5774
Country: CHINA
ProdList: 146
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

145022-92-0, Tauro--muricholic Acid (sodium salt)Related Search:

Tauro-β-muricholic acid sodium

T-βMCA sodium

Tauro-β-muricholic Acid sodium salt

2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt

Tauro-β-Muricholic Acid-[d5] Sodium Salt

D4-Tauro-β-muricholic Acid Sodium Salt

Tauro-muricholic Acid (sodium salt)

145022-92-0