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Tauro--muricholic Acid (sodium salt)

Product Name
Tauro--muricholic Acid (sodium salt)
CAS No.
145022-92-0
Chemical Name
Tauro--muricholic Acid (sodium salt)
Synonyms
T-βMCA sodium;Tauro-β-muricholic acid sodium;Tauro-β-muricholic Acid sodium salt;Tauro-muricholic Acid (sodium salt);D4-Tauro-β-muricholic Acid Sodium Salt;Tauro-β-Muricholic Acid-[d5] Sodium Salt;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt
CBNumber
CB24667085
Molecular Formula
C26H46NNaO7S
Formula Weight
539.7
MOL File
145022-92-0.mol
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Tauro--muricholic Acid (sodium salt) Property

Melting point:
120-125oC
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Pale Beige
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20289
Product name
Tauro-β-muricholic Acid (sodium salt)
Purity
≥95%
Packaging
500μg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
20289
Product name
Tauro-β-muricholic Acid (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
20289
Product name
Tauro-β-muricholic Acid (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$424
Updated
2024/03/01
TRC
Product number
T009135
Product name
Tauro-β-muricholicAcidSodiumSalt
Packaging
0.5mg
Price
$215
Updated
2021/12/16
AK Scientific
Product number
3131EL
Product name
Tauro-beta-muricholicacid(sodium)
Packaging
1mg
Price
$248
Updated
2021/12/16
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Tauro--muricholic Acid (sodium salt) Chemical Properties,Usage,Production

Description

Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid . TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor. TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.

Uses

Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies.

in vivo

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

Animal Model:APCmin/+ mice[3]
Dosage:400 mg/kg
Administration:Oral gavage; twice a week; for 6 weeks
Result:Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.

References

[1] SAMA I SAYIN. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.[J]. Cell metabolism, 2013, 17 2: 225-235. DOI: 10.1016/j.cmet.2013.01.003
[2] A. WAHLSTR?M. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota[S][J]. Journal of Lipid Research, 2017, 58 1: 412-419. DOI: 10.1194/jlr.m072819
[3] YUNPENG QI . Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 1: Pages 19-29. DOI: 10.1016/j.bbalip.2014.04.008

Tauro--muricholic Acid (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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Tauro--muricholic Acid (sodium salt) Suppliers

China 37 India 1 United States 6 Global 44
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
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sales-cpd@caerulumpharma.com
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China
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BOC Sciences
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16314854226
Email
info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Chengdu Push Bio-Technology Co., Ltd.
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028-028-85370565-229-229 18080489829
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18080489829@163.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Manhag Testing Technology Co., Ltd
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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China
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145022-92-0, Tauro--muricholic Acid (sodium salt)Related Search:


  • Tauro-β-muricholic acid sodium
  • T-βMCA sodium
  • Tauro-β-muricholic Acid sodium salt
  • 2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt
  • Tauro-β-Muricholic Acid-[d5] Sodium Salt
  • D4-Tauro-β-muricholic Acid Sodium Salt
  • Tauro-muricholic Acid (sodium salt)
  • 145022-92-0