RV521

Product Name: RV521
CAS No.: 1903763-82-5
Chemical Name: RV521
Synonyms: RV521;Sisunatovir;RV521 free base;RV521/Sisunatovir;Sisunatovir/RV521;Sisunatovir (Synonyms: RV521);1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one;1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one;Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6'-fluoro-;1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl}-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one
CBNumber: CB24668471
Molecular Formula: C23H22F4N4O
Formula Weight: 446.44
MOL File: 1903763-82-5.mol

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RV521 Property

Boiling point:: 651.9±55.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 3.33 mg/mL (7.46 mM; Need ultrasonic)
pka: 8.75±0.50(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2
InChIKey: JOPCJJSYRPUEDS-UHFFFAOYSA-N
SMILES: C12(C3=C(N(CC4N(CCCC(F)(F)F)C5=CC=C(CN)C=C5N=4)C1=O)C=C(F)C=C3)CC2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 100mg
Price: $1150
Updated: 2021/12/16

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RV521 Chemical Properties,Usage,Production

Uses

Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice[1].

in vivo

Sisunatovir (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection^[1].

References

[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19. Published 2020 Jan 27. DOI:10.1128/AAC.01884-19

RV521 Preparation Products And Raw materials

Raw materials

Preparation Products

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RV521 Suppliers

China 47 United States 3 Global 50

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengpharma@126.co 18616377689
Email: nanfengpharma@126.com
Country: China
ProdList: 20009
Advantage: 58

Soochow Chirally Material Science and Technology Co.,Ltd

Tel: 0512-66834346 17751187418
Email: sales@krl-tech.com
Country: China
ProdList: 1172
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 1490
Advantage: 62

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 8556
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
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1903763-82-5, RV521Related Search:

RV521

Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6'-fluoro-

Sisunatovir (Synonyms: RV521)

Sisunatovir

RV521 free base

1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl}-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one

1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one

1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one

Sisunatovir/RV521

RV521/Sisunatovir

1903763-82-5