TVB-3166

Product Name: TVB-3166
CAS No.: 1533438-83-3
Chemical Name: TVB-3166
Synonyms: TVB-3166;TVB-3166,TVB3166;TVB-3166 >=98% (HPLC);TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN);4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile;Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-
CBNumber: CB24670650
Molecular Formula: C24H24N4O
Formula Weight: 384.47
MOL File: 1533438-83-3.mol

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TVB-3166 Property

Boiling point:: 641.5±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:5.0(Max Conc. mg/mL);13.0(Max Conc. mM)
form: powder
pka: 14.66±0.50(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1694
Product name: TVB-3166
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1694
Product name: TVB-3166
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $530
Updated: 2023/06/20

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 100mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 10mg
Price: $170
Updated: 2021/12/16

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TVB-3166 Chemical Properties,Usage,Production

Biochem/physiol Actions

TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.

TVB-3166 Preparation Products And Raw materials

Raw materials

Preparation Products

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TVB-3166 Suppliers

CHINA 30 United States 4 Global 34

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
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Shanghai XingMo Biotechnology Co., Ltd.

Tel: +86 13524779951; 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 309
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghaizehan biopharma technology co., Ltd.

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Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7296
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Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
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Email: amber@biochempartner.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

1533438-83-3, TVB-3166Related Search:

TVB-3166

TVB-3166,TVB3166

Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-

TVB-3166 >=98% (HPLC)

4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile

TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN)

1533438-83-3