ChemicalBook > CAS DataBase List > (2S,4R)-4-METHYLGLUTAMIC ACID

(2S,4R)-4-METHYLGLUTAMIC ACID

Product Name
(2S,4R)-4-METHYLGLUTAMIC ACID
CAS No.
31137-74-3
Chemical Name
(2S,4R)-4-METHYLGLUTAMIC ACID
Synonyms
SYM 2081;(2S,4R)-4-MethylglutamicAci;(2S-R)-4-METHYLGLUTAMIC ACID;(2S,4R)-4-METHYLGLUTAMIC ACID;(4R)- 4-Methyl-L-glutamic Acid;L-erythro--Methylglutamic Acid;erythro-L-4-Methylglutamic Acid;ERYTHRO-4-METHYL-L-GLUTAMIC ACID;L-Glutamic acid, 4-methyl-, (4R)-;(2S,4R)-4-METHYLGLUTAMIC ACID USP/EP/BP
CBNumber
CB2468367
Molecular Formula
C6H11NO4
Formula Weight
161.16
MOL File
31137-74-3.mol
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(2S,4R)-4-METHYLGLUTAMIC ACID Property

Melting point:
178 °C
Boiling point:
287.44°C (rough estimate)
Density 
1.3482 (rough estimate)
refractive index 
1.4230 (estimate)
storage temp. 
Store at RT
solubility 
H2O: >10 mg/mL
form 
solid
pka
2.34±0.21(Predicted)
color 
white
InChI
InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
InChIKey
KRKRAOXTGDJWNI-DMTCNVIQSA-N
SMILES
C(O)(=O)[C@H](C[C@@H](C)C(O)=O)N
CAS DataBase Reference
31137-74-3(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0903
Product name
SYM2081
Purity
≥97%(HPLC)
Packaging
10
Price
$214
Updated
2021/12/16
TRC
Product number
M311575
Product name
(2S,4R)-4-MethylglutamicAcid
Packaging
50mg
Price
$1050
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0000080
Product name
(2S,4R)-4-METHYL GLUTAMIC ACID
Purity
95.00%
Packaging
50MG
Price
$1732.5
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11968
Product name
(2S,4R)-4-MethylglutamicAcid
Packaging
25mg
Price
$2000
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0000080
Product name
(2S,4R)-4-METHYL GLUTAMIC ACID
Purity
95.00%
Packaging
5MG
Price
$209
Updated
2021/12/16
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(2S,4R)-4-METHYLGLUTAMIC ACID Chemical Properties,Usage,Production

Chemical Properties

White

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .

IC 50

Kainate Receptor

(2S,4R)-4-METHYLGLUTAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,4R)-4-METHYLGLUTAMIC ACID Suppliers

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31137-74-3, (2S,4R)-4-METHYLGLUTAMIC ACIDRelated Search:

(2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE D,L-2-METHYLGLUTAMIC ACID HEMIHYDRATE, 9 9%,DL-2-METHYLGLUTAMIC ACID,DL-methylglutamic acid hemihydrate Z-L-GLA(OTBU)2-OH (2S,4R)-4-METHYLGLUTAMIC ACID (+/-)-1-AMINOCYCLOPENTANE-CIS-1,3-DICARBOXYLIC ACID (1S,3R)-ACPD DCG IV 4-DIMETHYL-L-GLUTAMIC ACID 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID H-GLA-OH L-CIS-PYRROLIDINE-2,4-DICARBOXYLIC ACID (2S,3R,4S)-CCG FMOC-GLA(OTBU)2-OH (2S,4S)-4-METHYLGLUTAMIC ACID HYDROCHLORIDE D-2-Methylglutamic acid (2R,3R)-3-Methylglutamic acid (R)-2-AMINO-2-METHYLPENTANEDIOIC ACID (2S,4S)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID,(2S,4S)-4-METHYLGLUTAMIC ACID,L-threo--Methylglutamic Acid

  • SYM 2081
  • ERYTHRO-4-METHYL-L-GLUTAMIC ACID
  • (2S,4R)-(+)-2-Amino-4-methylpentanedioic acid
  • (2S,4R)-4-METHYLGLUTAMIC ACID
  • (2S,4R)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID 99%
  • (2S-R)-4-METHYLGLUTAMIC ACID
  • (4R)- 4-Methyl-L-glutamic Acid
  • erythro-L-4-Methylglutamic Acid
  • L-erythro--Methylglutamic Acid
  • (2S,4R)-(+)-2-Amino-4-methylpentanedioic acid,99%
  • L-Glutamic acid, 4-methyl-, (4R)-
  • (2S,4R)-4-MethylglutamicAci
  • (2S,4R)-4-METHYLGLUTAMIC ACID USP/EP/BP
  • 31137-74-3
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Chiral Reagents
  • Neurochemicals