E3 ligase Ligand-Linker Conjugates 12

Product Name: E3 ligase Ligand-Linker Conjugates 12
CAS No.: 1797406-80-4
Chemical Name: E3 ligase Ligand-Linker Conjugates 12
Synonyms: VH032-PEG3-N3;(S,R,S)-AHPC-PEG?-azide;(S,R,S)-AHPC-PEG3-azide;VHL Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3);E3 ligase Ligand-Linker Conjugates 12;(S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3;L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber: CB24694700
Molecular Formula: C30H43N7O7S
Formula Weight: 645.78
MOL File: 1797406-80-4.mol

More

Less

E3 ligase Ligand-Linker Conjugates 12 Property

storage temp.: 2-8°C
form: Oil
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 904651
Product name: (S,R,S)-AHPC-PEG3-azide
Purity: ≥95%
Packaging: 50mg
Price: $549
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1610
Product name: (S,R,S)-AHPC-PEG3-N3
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

More

Less

E3 ligase Ligand-Linker Conjugates 12 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₃-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 12 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

E3 ligase Ligand-Linker Conjugates 12 Suppliers

China 23 United States 3 Global 26

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4825
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6037 18920794737
Email: sales@heowns.com
Country: China
ProdList: 23094
Advantage: 60

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1467
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Shaanxi borno biotechnology co., LTD

Tel: +86-13759708231
Email: asherw9@hotmail.com
Country: China
ProdList: 2373
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

More

Less

View Lastest Price from E3 ligase Ligand-Linker Conjugates 12 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG3-azide 1797406-80-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

1797406-80-4, E3 ligase Ligand-Linker Conjugates 12Related Search:

E3 ligase Ligand-Linker Conjugates 12

(S,R,S)-AHPC-PEG3-azide

VH032-PEG3-N3

VHL Ligand-Linker Conjugates 8

(S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3

(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

(S,R,S)-AHPC-PEG?-azide

(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3)

1797406-80-4