ChemicalBook > CAS DataBase List > E3 ligase Ligand-Linker Conjugates 12
E3 ligase Ligand-Linker Conjugates 12
- Product Name
- E3 ligase Ligand-Linker Conjugates 12
- CAS No.
- 1797406-80-4
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 12
- Synonyms
- VH032-PEG3-N3;(S,R,S)-AHPC-PEG?-azide;(S,R,S)-AHPC-PEG3-azide;VHL Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3);E3 ligase Ligand-Linker Conjugates 12;(S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3;L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber
- CB24694700
- Molecular Formula
- C30H43N7O7S
- Formula Weight
- 645.78
- MOL File
- 1797406-80-4.mol
More
Less
E3 ligase Ligand-Linker Conjugates 12 Property
- storage temp.
- 2-8°C
- form
- Oil
- color
- Colorless to light yellow
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 904651
- Product name
- (S,R,S)-AHPC-PEG3-azide
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $549
- Updated
- 2024/03/01
Iris Biotech GmbH
- Product number
- PTC1610
- Product name
- (S,R,S)-AHPC-PEG3-N3
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
More
Less
E3 ligase Ligand-Linker Conjugates 12 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG3-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reaction type: click chemistry
reagent type: ligand-linker conjugate
E3 ligase Ligand-Linker Conjugates 12 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
E3 ligase Ligand-Linker Conjugates 12 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- United States
- ProdList
- 6773
- Advantage
- 87
More
Less
View Lastest Price from E3 ligase Ligand-Linker Conjugates 12 manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- (S,R,S)-AHPC-PEG3-azide 1797406-80-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >99.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01