AIF Antibody
Source Reactivity Background References- Product Name
- AIF Antibody
- Chemical Name
- AIF Antibody
- Synonyms
- AIF Antibody;Mouse Monoclonal AIF Antibody
- CBNumber
- CB24699624
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb97351
- Product name
- AIF antibody
- Purity
- Ascitic fluid
- Packaging
- 100μL
- Price
- $370.6
- Updated
- 2021/12/16
- Product number
- orb10070
- Product name
- AIF antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb10071
- Product name
- AIF antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb74401
- Product name
- AIF antibody
- Packaging
- 100μL
- Price
- $584.8
- Updated
- 2021/12/16
- Product number
- orb74411
- Product name
- AIF antibody
- Packaging
- 100μL
- Price
- $584.8
- Updated
- 2021/12/16
AIF Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
Apoptosis-inducing factor is a ubiquitously expressed flavoprotein that plays a critical role in caspase-independent apoptosis. AIF is normally localized to the mitochondrial intermembrane space and released in response to apoptotic stimuli. Treatment of isolated nuclei with recombinant AIF leads to early apoptotic events, such as chromatin condensation and large-scale DNA fragmentation. Studies of AIF knockout mice have shown that the apoptotic activity of AIF is cell type and stimuli-dependent. Also noted was that AIF was required for embryoid body cavitation, representing the first wave of programmed cell death during embryonic morphogenesis. Structural analysis of AIF revealed two important regions, the first having oxidoreductase activity and the second being a potential DNA binding domain. While AIF is redox-active and can behave as an NADH oxidase, this activity is not required for inducing apoptosis. Instead, recent studies suggest that AIF has dual functions, a pro-apoptotic activity in the nucleus via its DNA binding and an anti-apoptotic activity via the scavenging of free radicals through its oxidoreductase activity.
References
[1] Daugas, E. et al. (2000) FEBS Lett 476, 118-23.
[2] Lipton, S.A. and Bossy-Wetzel, E. (2002) Cell 111, 147-50.
[3] Susin, S.A. et al. (1999) Nature 397, 441-6.
[4] Joza, N. et al. (2001) Nature 410, 549-54.
[5] Ye, H. et al. (2002) Nat Struct Biol 9, 680-4.
[6] Miramar, M.D. et al. (2001) J Biol Chem 276, 16391-8.
[7] Klein, J.A. et al. (2002) Nature 419, 367-74.
AIF Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
AIF Antibody Suppliers
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 18007124176
- ipdshengwu@163.com
- Country
- China
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- 4801
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- Tel
- 027-65317797 13667154760
- 1096814016@qq.com
- Country
- China
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- Tel
- 400821347
- orders@novusbio.com
- Country
- China
- ProdList
- 6434
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- 027-19371278702 18008634902
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- Country
- China
- ProdList
- 3008
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- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
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- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
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- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
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- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6427
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- Tel
- 1-+1 484.791.3823 14847913823
- orders@rockland.com
- Country
- China
- ProdList
- 4881
- Advantage
- 58