ChemicalBook > CAS DataBase List > Quinidine sulfate dihydrate

Quinidine sulfate dihydrate

Product Name
Quinidine sulfate dihydrate
CAS No.
6591-63-5
Chemical Name
Quinidine sulfate dihydrate
Synonyms
Quinidin;Unii-J13S2394he;Pitayine Sodium;Chinidin Sodium;β-quinine Sodium;β-quinine Sodium;QUINIDINE SULFATE;(S) Quinine Sulfate;Quinidine sulfate CRS;QUINIDINE SULFATE 99+%
CBNumber
CB2471189
Molecular Formula
C20H26N2O6S
Formula Weight
422.5
MOL File
6591-63-5.mol
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Quinidine sulfate dihydrate Property

Melting point:
212-214 °C (dec.)(lit.)
alpha 
[α]D20 +260～+270° (c=5, dil. HCl.10min)
refractive index 
275 ° (C=2, 0.1mol/L HCl)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone.
color 
White to Off-White
Water Solubility 
Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml).
Sensitive 
Light Sensitive
Merck 
14,8060
InChIKey
AKYHKWQPZHDOBW-ZAXYGKDDNA-N
SMILES
[C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r|
CAS DataBase Reference
6591-63-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-20/21/22
Safety Statements 
13-36
RIDADR 
UN 2811 6.1/PG III
WGK Germany 
3
RTECS 
VA5605000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
2939200050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Q0875
Product name
Quinidine sulfate salt dihydrate
Packaging
10g
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3233
Product name
Quinidine Sulfate
Purity
pharmaceutical secondary standard, certified reference material
Packaging
1G
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1595509
Product name
Quinidine sulfate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
J60426
Product name
Quinidine sulfate dihydrate, 98+%
Packaging
5g
Price
$50.65
Updated
2024/03/01
Alfa Aesar
Product number
J60426
Product name
Quinidine sulfate dihydrate, 98+%
Packaging
25g
Price
$185.65
Updated
2024/03/01
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Quinidine sulfate dihydrate Chemical Properties,Usage,Production

Chemical Properties

Quinidine sulfate dihydrate is white to light yellow crystal powde

Uses

antiarrhythmic, antimalarial

Uses

Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.

brand name

Cin-Quin (Solvay Pharmaceuticals); Quinidex (Wyeth); Quinora (Schering).

General Description

Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Clinical Use

Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.

Quinidine sulfate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Quinidine sulfate dihydrate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Quinidine sulfate dihydrate 6591-63-5
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-25
Shaanxi Dideu Medichem Co. Ltd
Product
Quinidine sulfate dihydrate 6591-63-5
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Hebei Mojin Biotechnology Co., Ltd
Product
Quinidine sulfate dihydrate 6591-63-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-30

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