Menatetrenone

Product Name: Menatetrenone
CAS No.: 863-61-6
Chemical Name: Menatetrenone
Synonyms: Vitamin K2;MENAQUINONE;e3100;D00100;Glakay;kaytwo;mk(sub4);k2(sub20);Metetrenone;Vitamin MK-4
CBNumber: CB2471321
Molecular Formula: C31H40O2
Formula Weight: 444.65
MOL File: 863-61-6.mol

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Menatetrenone Property

Melting point:: 350C
Boiling point:: 494.59°C (rough estimate)
Density: 1.0461 (rough estimate)
refractive index: 1.5045 (estimate)
Flash point:: 2℃
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form: Solid
color: Light Yellow to Yellow Oil
InChIKey: DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference: 863-61-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: QL9279500
HS Code: 2914699000
Toxicity: LD50 intravenous in dog: > 40mL/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V9378
Product name: Vitamin K2
Packaging: 1g
Price: $409
Updated: 2024/03/01

Sigma-Aldrich

Product number: V-031
Product name: Vitamin K2 (MK-4) solution
Purity: 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47774
Product name: Menaquinone (K2)
Purity: analyticalstandard
Packaging: 100mg
Price: $44.9
Updated: 2024/03/01

Cayman Chemical

Product number: 18423
Product name: Menaquinone 4
Purity: ≥98%
Packaging: 100mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 18423
Product name: Menaquinone 4
Purity: ≥98%
Packaging: 1g
Price: $312
Updated: 2024/03/01

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Menatetrenone Chemical Properties,Usage,Production

Description

Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

Chemical Properties

A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.

Occurrence

Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Definition

ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.

Preparation

It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.

General Description

Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

Biochem/physiol Actions

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

References

https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone

Menatetrenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Menatetrenone Suppliers

Canada 1 China 235 Europe 2 Germany 1 India 11 Switzerland 1 United Kingdom 1 United States 21 USA 1 Global 274

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View Lastest Price from Menatetrenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Menatetrenone 863-61-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500KGS
Release date: 2021-06-15

Hebei Weibang Biotechnology Co., Ltd

Product: Menatetrenone 863-61-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Menatetrenone 863-61-6
Price: US $30.00-13.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-14

863-61-6, MenatetrenoneRelated Search:

Acetonitrile DL-CARNITINE Tetraphenylcyclopentadienone Methanol 1,3,5,7-Cyclooctatetraene Methylparaben 2-Methylnaphthalene Paraquat dichloride METHYLCYCLOPENTADIENE DIMER 2,4,4-TRIMETHYL-1-PENTENE 6-Methyl-5-hepten-2-one Menadione Basic Violet 1 Methyl acetate Allyl methacrylate B12 VITAMIN B12 Norandrostenedione 1,2-NAPHTHOQUINONE

MENATETRENONE

MENAQUINONE 4

MENAQUINONE

1,4-naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen

2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoqu

2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone

e3100

k2(sub20)

menatetranone

Menaquinone4, Menatetrenone

Menaquinone4, Menatetrenone, VitaminK2

2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone

Menaquinone K4

Vitamin MK-4

D00100

Menatetrenone (jp15/inn)

Vitamin K2 (tn)

menaquinon-4

VITAMIN K2(MENAQUINONE-4)(SH)

Vitamin K2(MK-4)

Metetrenone

Vitamin K2 (MK-4) solution

Vitamin K2(20),MK4 0.13%

Vitamin K2(20),MK4 1.3% oil

Vitamin K2(20),MK4 1.3% powder

Vitamin K2(20),MK-4 JP14 powder

2-Methyl-3-geranylgeranyl-1,4-naphthoquinone

Glakay

Menaquinone 4 (Mixture of cis-trans isoMers)

Menatetrenone(11032-49-8)

kaytwo

menaquinonek(sub4)

mk(sub4)

vitamink2(sub20)

Phytonadione,(Z)

MENAQUINONE (K2) 100MG NEAT

VitaminK2(20)0.13%Oil

VitaminK2(45)98.0%Min.Powder

VitaminK2(20)

VitaminK2(20)1.3%Powder

VitaminK2(20)98.0%Oil

VitaminK2(20)98.0%Powder

VitaminK2(20)0.13%Powder

VitaminK2(20)1.3%Oil

(E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione

2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione

Vitamin K2

Vitamin K2(20),MK4 0.13% powder

Vitamin K2,MK4,menaquinone, menaquinon-4, menatetrenone, menatetren, menatetrenona, menatetrenonum

Vitamin K2-Menatetrenone ( MK-4 )

Menatetrenone (MK-4)

vitamin K2 Menatetrenone

Menatetrenone RS

Menaquinone-4 Standard

1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-

Menatetrenone USP/EP/BP

2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione

Menatetrenone (Vitamin MK4, E3100)