TAS-115 Methanesulfonic acid salt
- Product Name
- TAS-115 Methanesulfonic acid salt
- CAS No.
- 1688673-09-7
- Chemical Name
- TAS-115 Methanesulfonic acid salt
- Synonyms
- TAS115;TAS 115;TAS-115 mesylate;Pamufetinib (mesylate);TAS-115 methanesulfonate;Pamufetinib (TAS-115) mesylate;TAS-115 Methanesulfonic acid salt;TAS-115 mesylate (TAS-115 methanesulfonate);TAS-115 mesylate (Synonyms: TAS-115 methanesulfonate)
- CBNumber
- CB24732343
- Molecular Formula
- C28H27FN4O7S2
- Formula Weight
- 614.66
- MOL File
- 1688673-09-7.mol
TAS-115 Methanesulfonic acid salt Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: slightly soluble; PBS (pH 7.2): slightly soluble; Water: slightly soluble
- form
- A crystalline solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0081113
- Product name
- TAS-115mesylate
- Purity
- 99.15%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0081113
- Product name
- TAS-115mesylate
- Purity
- 99.15%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0081113
- Product name
- TAS-115mesylate
- Purity
- 99.15%
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- CS-0081113
- Product name
- TAS-115mesylate
- Purity
- 99.15%
- Packaging
- 100mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- DC12256
- Product name
- TAS-115mesylate(TAS-115methanesulfonate)
- Purity
- >98%
- Packaging
- 1g
- Price
- $3500
- Updated
- 2021/12/16
TAS-115 Methanesulfonic acid salt Chemical Properties,Usage,Production
Uses
Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
in vivo
Pamufetinib mesylate completely suppresses the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of Pamufetinib mesylate. Pamufetinib mesylate induces marked tumor shrinkage and prolonges survival in MET-amplified human cancer–bearing mice[1].
References
[1] Fujita H, et al. The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile. Mol Cancer Ther. 2013 Dec;12(12):2685-96. DOI:10.1158/1535-7163.MCT-13-0459
[2] Nakade J, et al. Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol. 2014 Jun;9(6):775-83. DOI:10.1097/JTO.0000000000000170
TAS-115 Methanesulfonic acid salt Preparation Products And Raw materials
Raw materials
Preparation Products
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