1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Product Name
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- CAS No.
- 4004-05-1
- Chemical Name
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Synonyms
- DOPE;1,2-Dioleoyl-sn-glycero-3-PE;(Z)-(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate;18:1 PE;PE(18:1(9Z)/18:1(9Z));COATSOME ME-8181 (DOPE);L-β,γ-Dioleoyl-α-cephalin;L-β,γ-Dioleoyl-α-Cephalin;18:1 (Delta9-Cis) PE (DOPE);Dioleoyl phosphoethanolamine
- CBNumber
- CB2477530
- Molecular Formula
- C41H78NO8P
- Formula Weight
- 744.05
- MOL File
- 4004-05-1.mol
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Property
- Melting point:
- 200°C(lit.)
- Boiling point:
- 759.2±70.0 °C(Predicted)
- Density
- 1.008±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 31.25 mg/mL (42.00 mM)
- pka
- 1.17±0.50(Predicted)
- form
- lyophilized powder
- color
- White to Light yellow
- BRN
- 1718431
- InChIKey
- MWRBNPKJOOWZPW-XFBMKQTANA-N
- SMILES
- [C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r|
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-38-40-48/20/22-67-36/38-20-63
- Safety Statements
- 36/37-26
- RIDADR
- UN 1888 6.1/PG 3
- WGK Germany
- 3
- F
- 8-10-23
- HS Code
- 29232000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 42490
- Product name
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Purity
- ≥99.0% (10 mg phospholipid per ml CHCl3, TLC)
- Packaging
- 2.5ml
- Price
- $87.6
- Updated
- 2024/03/01
- Product number
- 42490
- Product name
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Purity
- ≥99.0% (10 mg phospholipid per ml CHCl3, TLC)
- Packaging
- 10ml
- Price
- $327
- Updated
- 2024/03/01
- Product number
- D4251
- Product name
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Purity
- >98.0%(T)
- Packaging
- 250mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 15091
- Product name
- 1,2-Dioleoyl-sn-glycero-3-PE
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15091
- Product name
- 1,2-Dioleoyl-sn-glycero-3-PE
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2024/03/01
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemical Properties,Usage,Production
Description
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral phospholipid and displays sensitivity towards pH change and has been used in the preparation of liposome and giant unilamellar vesicles (GUVs).
Phosphatidylethanolamine (PE) is formed primarily in the reaction of CDP-ethanolamine and diacylglycerol. PE is one of the major components of cell membranes in bacteria and in nervous system.
Chemical Properties
Yellowish wax
Uses
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.
Uses
1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
Uses
18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.
Definition
ChEBI: Dioleoyl phosphatidylethanolamine is a phosphatidylethanolamine in which the phosphatidyl acyl groups are both oleoyl.
General Description
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.
Biological Activity
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
Biochem/physiol Actions
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
storage
Store at -20°C
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine manufacturers
- Product
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 4004-05-1
- Price
- US $30.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 3 tons
- Release date
- 2023-10-24
- Product
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 4004-05-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- DOPE 4004-05-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle , 10g/bottle, 100g/bottle
- Release date
- 2024-07-26