AST2818 mesylate
- Product Name
- AST2818 mesylate
- CAS No.
- 2130958-55-1
- Chemical Name
- AST2818 mesylate
- Synonyms
- Alflutinib mesylate;Furmonertinib;AST2818 mesylate;ASK120067 mesylate;Furmonertinib mesylate;Firmonertinib mesylate;Alflutinib methanesulfonate;Alflutinib mesylate (AST2818);Alflutinib (AST2818 mesylate);Firmonertinib (AST2818) mesylate
- CBNumber
- CB24797023
- Molecular Formula
- C29H35F3N8O5S
- Formula Weight
- 664.71
- MOL File
- 2130958-55-1.mol
AST2818 mesylate Property
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble
- form
- A crystalline solid
- color
- Light yellow to yellow
- InChIKey
- WDPGHXINXNBHAS-UHFFFAOYSA-N
- SMILES
- S(O)(=O)(=O)C.CN1C2=CC=CC=C2C(C2C=CN=C(NC3C=C(NC(=O)C=C)C(N(C)CCN(C)C)=NC=3OCC(F)(F)F)N=2)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0067492
- Product name
- AST2818mesylate
- Purity
- 99.99%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0067492
- Product name
- AST2818mesylate
- Purity
- 99.99%
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0067492
- Product name
- AST2818mesylate
- Purity
- 99.99%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0067492
- Product name
- AST2818mesylate
- Purity
- 99.99%
- Packaging
- 100mg
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- orb573198
- Product name
- Alflutinib mesylate (AST2818)
- Packaging
- 100mg
- Price
- $1283.5
- Updated
- 2021/12/16
AST2818 mesylate Chemical Properties,Usage,Production
Description
Furmonertinib (formerly known as alflutinib) is another me-too third-generation EGFR TKI that has a pyridyl ring replacing the phenyl ring of osimertinib and a trifluoroethyl group replacing the methyl group (Fig. 4). This TKI, which was discovered and developed by Shanghai Allist Pharma, was approved in November 2019 by the NMPA of China for the second-line treatment of NSCLC with EGFR sensitive mutation and EGFR T790M drug-resistant mutation, and more recently as a first-line treatment for classical EGFR mutant NSCLC. In June 2022, furmonertinib was granted the Fast Track designation by the FDA in patients with advanced or metastatic NSCLC with activating EGFR or HER2 mutations, including exon 20 insertion mutations.
Uses
Firmonertinib (Alflutinib; Furmonertinib) mesylate is is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation[1].
IC 50
EGFR
References
[1] Y. Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.
[2] Alexander I. Spira, et al. FURVENT: Phase 3 trial of furmonertinib vs chemotherapy as first-line treatment for advanced NSCLC with EGFR exon 20 insertion mutations (FURMO-004). Journal of Clinical Oncology. Volume 42, Number 16_suppl
AST2818 mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AST2818 mesylate manufacturers
- Product
- AST2818 mesylate 2130958-55-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26