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AST2818 mesylate

Product Name
AST2818 mesylate
CAS No.
2130958-55-1
Chemical Name
AST2818 mesylate
Synonyms
Alflutinib mesylate;Furmonertinib;AST2818 mesylate;ASK120067 mesylate;Furmonertinib mesylate;Alflutinib methanesulfonate;Alflutinib mesylate (AST2818);Alflutinib (AST2818 mesylate);Alflutinib mesylate (Furmonertinib);N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate
CBNumber
CB24797023
Molecular Formula
C29H35F3N8O5S
Formula Weight
664.71
MOL File
2130958-55-1.mol
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AST2818 mesylate Property

storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067492
Product name
AST2818mesylate
Purity
99.99%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0067492
Product name
AST2818mesylate
Purity
99.99%
Packaging
10mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0067492
Product name
AST2818mesylate
Purity
99.99%
Packaging
50mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0067492
Product name
AST2818mesylate
Purity
99.99%
Packaging
100mg
Price
$1250
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573198
Product name
Alflutinib mesylate (AST2818)
Packaging
100mg
Price
$1283.5
Updated
2021/12/16
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AST2818 mesylate Chemical Properties,Usage,Production

Description

Furmonertinib (formerly known as alflutinib) is another me-too third-generation EGFR TKI that has a pyridyl ring replacing the phenyl ring of osimertinib and a trifluoroethyl group replacing the methyl group (Fig. 4). This TKI, which was discovered and developed by Shanghai Allist Pharma, was approved in November 2019 by the NMPA of China for the second-line treatment of NSCLC with EGFR sensitive mutation and EGFR T790M drug-resistant mutation, and more recently as a first-line treatment for classical EGFR mutant NSCLC. In June 2022, furmonertinib was granted the Fast Track designation by the FDA in patients with advanced or metastatic NSCLC with activating EGFR or HER2 mutations, including exon 20 insertion mutations.

AST2818 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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AST2818 mesylate Suppliers

China 42 United States 5 Global 47
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View Lastest Price from AST2818 mesylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
AST2818 mesylate 2130958-55-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

2130958-55-1, AST2818 mesylateRelated Search:


  • AST2818 mesylate
  • Alflutinib mesylate (AST2818)
  • Alflutinib methanesulfonate
  • Alflutinib mesylate
  • N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide compd. with methanesulfonate (1:1)
  • Alflutinib (AST2818 mesylate)
  • Alflutinib mesylate (Furmonertinib)
  • Furmonertinib mesylate
  • cancer,Epidermal growth factor receptor,AST2818,esistant mutation,Alflutinib,Alflutinib mesylate,AST-2818,Furmonertinib,HER1,AST 2818,NSCLC,ErbB-1,Inhibitor,EGFR,T790M,inhibit
  • N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate
  • ASK120067 mesylate
  • Furmonertinib
  • 2130958-55-1