ChemicalBook > CAS DataBase List > AST2818 mesylate

AST2818 mesylate

Product Name: AST2818 mesylate
CAS No.: 2130958-55-1
Chemical Name: AST2818 mesylate
Synonyms: Alflutinib mesylate;Furmonertinib;AST2818 mesylate;ASK120067 mesylate;Furmonertinib mesylate;Firmonertinib mesylate;Alflutinib methanesulfonate;Alflutinib mesylate (AST2818);Alflutinib (AST2818 mesylate);Firmonertinib (AST2818) mesylate
CBNumber: CB24797023
Molecular Formula: C29H35F3N8O5S
Formula Weight: 664.71
MOL File: 2130958-55-1.mol

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AST2818 mesylate Property

storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble
form: A crystalline solid
color: Light yellow to yellow
InChIKey: WDPGHXINXNBHAS-UHFFFAOYSA-N
SMILES: S(O)(=O)(=O)C.CN1C2=CC=CC=C2C(C2C=CN=C(NC3C=C(NC(=O)C=C)C(N(C)CCN(C)C)=NC=3OCC(F)(F)F)N=2)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0067492
Product name: AST2818mesylate
Purity: 99.99%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0067492
Product name: AST2818mesylate
Purity: 99.99%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0067492
Product name: AST2818mesylate
Purity: 99.99%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0067492
Product name: AST2818mesylate
Purity: 99.99%
Packaging: 100mg
Price: $1250
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573198
Product name: Alflutinib mesylate (AST2818)
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

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AST2818 mesylate Chemical Properties,Usage,Production

Description

Furmonertinib (formerly known as alflutinib) is another me-too third-generation EGFR TKI that has a pyridyl ring replacing the phenyl ring of osimertinib and a trifluoroethyl group replacing the methyl group (Fig. 4). This TKI, which was discovered and developed by Shanghai Allist Pharma, was approved in November 2019 by the NMPA of China for the second-line treatment of NSCLC with EGFR sensitive mutation and EGFR T790M drug-resistant mutation, and more recently as a first-line treatment for classical EGFR mutant NSCLC. In June 2022, furmonertinib was granted the Fast Track designation by the FDA in patients with advanced or metastatic NSCLC with activating EGFR or HER2 mutations, including exon 20 insertion mutations.

Uses

Firmonertinib (Alflutinib; Furmonertinib) mesylate is is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation[1].

IC 50

EGFR

References

[1] Y. Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.
[2] Alexander I. Spira, et al. FURVENT: Phase 3 trial of furmonertinib vs chemotherapy as first-line treatment for advanced NSCLC with EGFR exon 20 insertion mutations (FURMO-004). Journal of Clinical Oncology. Volume 42, Number 16_suppl

AST2818 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AST2818 mesylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AST2818 mesylate 2130958-55-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

2130958-55-1, AST2818 mesylateRelated Search:

AST2818 mesylate

Alflutinib mesylate (AST2818)

Alflutinib methanesulfonate

Alflutinib mesylate

N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide compd. with methanesulfonate (1:1)

Alflutinib (AST2818 mesylate)

Alflutinib mesylate (Furmonertinib)

Furmonertinib mesylate

cancer,Epidermal growth factor receptor,AST2818,esistant mutation,Alflutinib,Alflutinib mesylate,AST-2818,Furmonertinib,HER1,AST 2818,NSCLC,ErbB-1,Inhibitor,EGFR,T790M,inhibit

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate

ASK120067 mesylate

Furmonertinib

Firmonertinib (AST2818) mesylate

Alflutinib (Furmonertinib) mesylate

Firmonertinib mesylate

2130958-55-1