UT-155

Product Name: UT-155
CAS No.: 2031161-35-8
Chemical Name: UT-155
Synonyms: UT-155;UT-155, 10 mM in DMSO;UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155;(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide;1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-
CBNumber: CB24797104
Molecular Formula: C20H15F4N3O2
Formula Weight: 405.35
MOL File: 2031161-35-8.mol

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UT-155 Property

Boiling point:: 613.6±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);246.7(Max Conc. mM)
pka: 12.74±0.29(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C20H15F4N3O2/c1-19(29,11-27-7-6-12-8-14(21)3-5-17(12)27)18(28)26-15-4-2-13(10-25)16(9-15)20(22,23)24/h2-9,29H,11H2,1H3,(H,26,28)/t19-/s3
InChIKey: CFSAYQVTXBMPRF-DETXXQSHNA-N
SMILES: C(N1C=CC2=CC(F)=CC=C12)[C@@](O)(C)C(=O)NC1C=CC(C#N)=C(C(F)(F)F)C=1 |&1:11,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 100mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 250mg
Price: $3580.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 1g
Price: $7136.6
Updated: 2021/12/16

DC Chemicals

Product number: DC12102
Product name: UT-155
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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UT-155 Chemical Properties,Usage,Production

Uses

UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.

in vivo

Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, as expected, enzalutamide has no effect on the growth of the 22RV1 tumors. Tumor weights and PSA and the expression of AR and AR-SV are significantly lower in UT-155-treated animals^[1].

References

[1] Ponnusamy S, et al. Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer. Cancer Res. 2017 Nov 15;77(22):6282-6298. DOI:10.1158/0008-5472.CAN-17-0976

UT-155 Preparation Products And Raw materials

Raw materials

Preparation Products

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UT-155 Suppliers

China 46 United States 3 Global 49

Chengdu Celes Technology Co., Ltd

Tel: 19982073091
Email: 2538834896@qq.com
Country: China
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
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Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Chuzhou KeMail Chemical Technology Co., Ltd

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Twochem Co.Ltd.

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2031161-35-8, UT-155Related Search:

UT-155

1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-

UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155

UT-155, 10 mM in DMSO

(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide

2031161-35-8

2031131-35-8