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ODM203

Product Name
ODM203
CAS No.
1430723-35-5
Chemical Name
ODM203
Synonyms
ODM203;ODM-203 ，S8882;ODM-203, 10 mM in DMSO;N-[2',4'-Difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]cyclopropanesulfonamide;Cyclopropanesulfonamide, N-[2',4'-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]-;N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide;anti-tumor immunity,ODM-203,FGFR,HUVEC,H1581,Inhibitor,cancer,Vascular endothelial growth factor receptor,SNU16,ODM203,ODM 203,RT4,Fibroblast growth factor receptor,VEGFR,inhibit
CBNumber
CB24798611
Molecular Formula
C26H21F2N5O2S
Formula Weight
505.54
MOL File
1430723-35-5.mol
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ODM203 Property

Boiling point:
732.4±70.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 66.67 mg/mL (131.88 mM; Need ultrasonic)
form 
A crystalline solid
pka
7.88±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067923
Product name
ODM-203
Purity
99.33%
Packaging
5mg
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-0067923
Product name
ODM-203
Purity
99.33%
Packaging
10mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0067923
Product name
ODM-203
Purity
99.33%
Packaging
25mg
Price
$440
Updated
2021/12/16
ChemScene
Product number
CS-0067923
Product name
ODM-203
Purity
99.33%
Packaging
50mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-0067923
Product name
ODM-203
Purity
99.33%
Packaging
100mg
Price
$1150
Updated
2021/12/16
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ODM203 Chemical Properties,Usage,Production

Uses

ODM-203 is an orally active and selective FGFR/VEGFR inhibitor with IC50 values of 6, 11, 16, 5, 9, 26 and 35 nM for FGFR3/1/2 and VEGFR3/2/1/4, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment[1].

in vivo

ODM-203 (20, 40 mg/kg; p.o.; single daily for 21 days) inhibits FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts by suppressing FGFR signaling in tumors[1].
ODM-203 (7, 20, 40 mg/kg; p.o.; single daily for 21 days) shows strong anti-tumor activity in a VEGFR-dependent angiogenic orthotopic syngenic model (Renca) and suppresses angiogenesis[1].
ODM-203 (20, 40 mg/kg; p.o.; single daily for 5 days) activates immune response in the tumor microenvironment[1].

Animal Model:Athymic Nude-Foxn1nu female mice (9-week-old; subcutaneous xenograft models)[1].
Dosage:20, 40 mg/kg
Administration:Oral administration; single daily for 21 days.
Result:Significantly inhibited tumour growth for 21 consecutive days.
Showed tumor growth inhibition (TGI) in RT4 xenografts was 37% and 92% with dosage of 20 and 40 mg/kg, respectively.
Animal Model:Male balb/c mice (8-week-old; orthotopic renca syngenic model)[1].
Dosage:7, 20, 40 mg/kg
Administration:Oral administration; single daily for 21 days.
Result:Showed tumor growth inhibition were 39%, 58% and 75% for dosage of 7, 20 and 40 mg/kg, respectively.
Inhibited formation of lung metastasis, and suppressed angiogenesis.
Animal Model:Male balb/c male mice (5 to 7-week-old; renca subcutaneous tumor model)[1].
Dosage:20, 40 mg/kg
Administration:Oral administration; single daily for 5 days.
Result:Resulted in an increase in the percentage of total and CD4 T cells.
Decreased the expression of immune check points PD-1 and PD-L1 and increased IFN-γ expression on both CD8 T cells and NK cells.

IC 50

FGFR1: 11 nM (IC50); FGFR2: 16 nM (IC50); FGFR3: 6 nM (IC50); FGFR4: 35 nM (IC50); VEGFR1: 26 nM (IC50); VEGFR2: 9 nM (IC50); VEGFR3: 5 nM (IC50); DDR1: 6 nM (IC50); RET: 8 nM (IC50); SIK3: 23 nM (IC50); PDGFRa: 35 nM (IC50); MINK1: 41 nM (IC50); MAP4K4: 49 nM (IC50)

References

[1] Holmstr?m TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38. DOI:10.1158/1535-7163.MCT-18-0204

ODM203 Preparation Products And Raw materials

Raw materials

Preparation Products

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ODM203 Suppliers

China 60 United States 5 Global 65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1430723-35-5, ODM203Related Search:

ODM-201

  • ODM203
  • N-[2',4'-Difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]cyclopropanesulfonamide
  • Cyclopropanesulfonamide, N-[2',4'-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]-
  • N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide
  • anti-tumor immunity,ODM-203,FGFR,HUVEC,H1581,Inhibitor,cancer,Vascular endothelial growth factor receptor,SNU16,ODM203,ODM 203,RT4,Fibroblast growth factor receptor,VEGFR,inhibit
  • ODM-203, 10 mM in DMSO
  • ODM-203 ，S8882
  • 1430723-35-5