ChemicalBook > CAS DataBase List > ODM-201

ODM-201

Product Name
ODM-201
CAS No.
1297538-32-9
Chemical Name
ODM-201
Synonyms
Darolutamide;BAY-1841788;0DM021;ODM-201;ODM-021;ODM 021;CS-1565;Darolutamid;Darrolumide;Darolutamide D4
CBNumber
CB43052901
Molecular Formula
C19H19ClN6O2
Formula Weight
398.85
MOL File
1297538-32-9.mol
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ODM-201 Property

Melting point:
169 - 171°C
Boiling point:
719.5±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
11.10±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25643
Product name
ODM-201
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25643
Product name
ODM-201
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
25643
Product name
ODM-201
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
25643
Product name
ODM-201
Purity
≥98%
Packaging
25mg
Price
$692
Updated
2024/03/01
TRC
Product number
O006500
Product name
ODM-201
Packaging
100mg
Price
$1890
Updated
2021/12/16
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ODM-201 Chemical Properties,Usage,Production

Description

ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

Description

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

Uses

ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.

References

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 Preparation Products And Raw materials

Raw materials

Preparation Products

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ODM-201 Suppliers

Deyang Sino Biotech. Co., LTD
Tel
+86-19182167371 +86-19182167371
Email
service@synlord.com
Country
China
ProdList
99
Advantage
58
Changzhou Yongfeng Biomedicine Co. Ltd.
Tel
15006117673
Fax
2973592490@.com
Email
2973592490@qq.com
Country
China
ProdList
306
Advantage
58
Chengdu Celes Technology Co., Ltd
Tel
17323066073
Email
2538834896@qq.com
Country
China
ProdList
79
Advantage
58
Yichang Chanod Biomedical Technology Co,LTD
Tel
0717-6855399 15377615856
Email
sales@sndswyy.cn
Country
China
ProdList
77
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
5595
Advantage
58
Hunan Furui Biopharma Technology Co., Ltd.
Tel
15902102743
Fax
0731-57805668
Email
shelley@furuipharma.com
Country
China
ProdList
452
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7189
Advantage
65
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9461
Advantage
58
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View Lastest Price from ODM-201 manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
ODM-201 1297538-32-9
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Wuhan Nutra Biotechnology Co.,Ltd
Product
ODM-201;Darolutamide;BAY-1841788 1297538-32-9
Price
US $285.00-0.00/g
Min. Order
1ASSAYS
Purity
98%+
Supply Ability
10kgs
Release date
2021-05-21
Hebei Dangtong Import and export Co LTD
Product
ODM-201 1297538-32-9
Price
US $40.00-35.00/Gram
Min. Order
1Gram
Purity
99.99%
Supply Ability
50Tons
Release date
2023-04-11

1297538-32-9, ODM-201Related Search:


  • CS-1565
  • ODM-201(Darolutamide)
  • N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
  • 0DM021
  • BAY-1841788;ODM-021;0DM021;ODM 021
  • ODM 021
  • ODM-021
  • ODM-201
  • BAY-1841788
  • N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
  • Darolutamide
  • N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
  • Darolutamide (ODM-201)
  • ODM-201(BAY-1841788)
  • DAROLUTAMIDE;BAY-1841788
  • 1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-
  • Darolutamid
  • Darolutamide D4
  • N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)Chemicalbook-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
  • TIANFUCHEM--1297538-32-9---ODM-201
  • N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
  • N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide
  • Dantrolene Impurity 6
  • Darolutamide, ODM-201,BAY-1841788
  • Darrolumide
  • 1297538-32-9
  • C19H19ClN6O2
  • API