ODM-201
- Product Name
- ODM-201
- CAS No.
- 1297538-32-9
- Chemical Name
- ODM-201
- Synonyms
- Darolutamide;BAY-1841788;0DM021;ODM-201;ODM-021;ODM 021;CS-1565;Darolutamid;Darrolumide;Darolutamide D4
- CBNumber
- CB43052901
- Molecular Formula
- C19H19ClN6O2
- Formula Weight
- 398.85
- MOL File
- 1297538-32-9.mol
ODM-201 Property
- Melting point:
- 169 - 171°C
- Boiling point:
- 719.5±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 11.10±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25643
- Product name
- ODM-201
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 25643
- Product name
- ODM-201
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 25643
- Product name
- ODM-201
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 25643
- Product name
- ODM-201
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $692
- Updated
- 2024/03/01
- Product number
- O006500
- Product name
- ODM-201
- Packaging
- 100mg
- Price
- $1890
- Updated
- 2021/12/16
ODM-201 Chemical Properties,Usage,Production
Description
ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.
Description
ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
Uses
ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.
References
Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.
ODM-201 Preparation Products And Raw materials
Raw materials
Preparation Products
ODM-201 Suppliers
- Tel
- 19182167371 19182167371
- service@synlord.com
- Country
- China
- ProdList
- 93
- Advantage
- 58
- Tel
- 15006117673
- Fax
- 2973592490@.com
- 2973592490@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3574
- Advantage
- 58
- Tel
- 0717-6855399 15377615856
- sales@sndswyy.cn
- Country
- China
- ProdList
- 84
- Advantage
- 58
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 5477
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 822
- Advantage
- 65
- Tel
- 0551-68779238 18056025720
- sales3@lcywhx.com
- Country
- China
- ProdList
- 168
- Advantage
- 57
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 6854
- Advantage
- 65
- Tel
- +86-028-60911900 13540204019
- sales@afbiochem.com
- Country
- China
- ProdList
- 493
- Advantage
- 57
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9449
- Advantage
- 58
- Tel
- 021-34666753 13311639313
- Fax
- +86-21-34979012
- info@shyrchem.com
- Country
- China
- ProdList
- 571
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9634
- Advantage
- 58
- Tel
- 400-6087598 15021221957
- Fax
- 4006087598-8012
- order@canspecsci.com
- Country
- China
- ProdList
- 2071
- Advantage
- 56
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 0571-89081561; 10006559855
- Fax
- 0571 89081561
- info@cheminspire.com
- Country
- China
- ProdList
- 412
- Advantage
- 58
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- 21-619849051-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6456
- Advantage
- 55
- Tel
- 19138486554 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 2862
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 021-31761238 13167072949
- Fax
- 021-31761238
- 3146446224@qq.com
- Country
- China
- ProdList
- 1610
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2993
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9038
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29796
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1836
- Advantage
- 55
- Tel
- 0556-5800026 17709662922
- melrose@worldpharma.cn
- Country
- China
- ProdList
- 218
- Advantage
- 55
- Tel
- +86-530-529 6766,+86-15666160102 15666160102
- Fax
- 0530-529 6766
- info@chuangli-chem.com
- Country
- China
- ProdList
- 876
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 0573-86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 7960
- Advantage
- 58
- Tel
- 0755-0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9294
- Advantage
- 58
- Tel
- +86-18017644823
- Fax
- - QQ:1910610264
- sales@betterbiochem.com
- Country
- China
- ProdList
- 325
- Advantage
- 58
- Tel
- 021-61469567 18521078705
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 19977
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- 495745175@qq.com
- Country
- China
- ProdList
- 6700
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 15502154572
- Fax
- -
- yuben012@sina.com
- Country
- China
- ProdList
- 502
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3244
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 9944
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1018
- Advantage
- 58
View Lastest Price from ODM-201 manufacturers
- Product
- ODM-201 1297538-32-9
- Price
- US $40.00-35.00/Gram
- Min. Order
- 1Gram
- Purity
- 99.99%
- Supply Ability
- 50Tons
- Release date
- 2023-04-11
- Product
- ODM-201 1297538-32-9
- Price
- US $9.00-70.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-27
- Product
- ODM-201 1297538-32-9
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-07-18