ChemicalBook > CAS DataBase List > ODM-201

ODM-201

Product Name: ODM-201
CAS No.: 1297538-32-9
Chemical Name: ODM-201
Synonyms: Darolutamide;BAY-1841788;0DM021;ODM-201;ODM-021;ODM 021;CS-1565;Darotaxime;Darolutamid;Darrolumide
CBNumber: CB43052901
Molecular Formula: C19H19ClN6O2
Formula Weight: 398.85
MOL File: 1297538-32-9.mol

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ODM-201 Property

Melting point:: 169 - 171°C
Boiling point:: 719.5±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.10±0.10(Predicted)
form: Solid
color: White to Off-White
InChIKey: BLIJXOOIHRSQRB-PXYINDEMSA-N
SMILES: N1C(C(O)C)=CC(C(N[C@@H](C)CN2C=CC(C3=CC=C(C#N)C(Cl)=C3)=N2)=O)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25643
Product name: ODM-201
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 25643
Product name: ODM-201
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 25643
Product name: ODM-201
Purity: ≥98%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 25643
Product name: ODM-201
Purity: ≥98%
Packaging: 25mg
Price: $692
Updated: 2024/03/01

TRC

Product number: O006500
Product name: ODM-201
Packaging: 100mg
Price: $1890
Updated: 2021/12/16

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ODM-201 Chemical Properties,Usage,Production

Description

ODM-201 is an androgen receptor (AR) antagonist (K_i = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC₅₀s = 65, 66, 1,500, and 1,782 nM for wild-type, AR^F876L, AR^W741L, and AR^T877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC₅₀ = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

Description

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

Uses

ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.

Biological Activity

As a ligand-dependent transcription factor, androgen receptor(AR) controls the expression of multiple genes involved in cell growth and survival. Darolutamide is able to inhibit multiple AR variants that confer resistance to first-generation antagonists.

Synthesis

Synthesis of Darolutamide

in vivo

Darolutamide (ODM-201) showes a significant antitumor activity with both doses, 50 mg/kg twice daily being more efficacious compared to castrated, untreated mice (p<0.001), which also showes inhibition of tumor growth (p<0.05) vs. castrated, untreated mice. Further, there is no sign of treatment-related toxicities; the body weights of mice treated with Darolutamide twice daily do not decrease significantly during the treatment^[1].

References

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 Preparation Products And Raw materials

Raw materials

Preparation Products

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ODM-201 Suppliers

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View Lastest Price from ODM-201 manufacturers

Shandong Hanjiang Chemical Co., Ltd

Product: Darolutamide 1297538-32-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2025-10-16

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: ODM-201 1297538-32-9
Price: US $1000.00-400.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-12

Hebei Dangtong Import and export Co LTD

Product: ODM-201 1297538-32-9
Price: US $40.00-35.00/Gram
Min. Order: 1Gram
Purity: 99.99%
Supply Ability: 50Tons
Release date: 2023-04-11

1297538-32-9, ODM-201Related Search:

ODM203 Defactinib PF 04554878 hydrochloride

CS-1565

ODM-201(Darolutamide)

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide

0DM021

BAY-1841788;ODM-021;0DM021;ODM 021

ODM 021

ODM-021

ODM-201

BAY-1841788

N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

Darolutamide

N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

Darolutamide (ODM-201)

ODM-201(BAY-1841788)

DAROLUTAMIDE;BAY-1841788

1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-

Darolutamid

Darolutamide D4

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)Chemicalbook-1-hydroxyethyl]-1H-pyrazole-3-carboxamide

TIANFUCHEM--1297538-32-9---ODM-201

N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide

Darolutamide, ODM-201,BAY-1841788

Darrolumide

Dantrolene Impurity 6

Darolutamide, 10 mM in DMSO

Darotaxime

1297538-32-9

C19H19ClN6O2

API